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Recent Progress in Antibody Epitope Prediction [PDF]

Antibodies, 2023
Recent progress in epitope prediction has shown promising results in the development of vaccines and therapeutics against various diseases. However, the overall accuracy and success rate need to be improved greatly to gain practical application ...
Xincheng Zeng, Ganggang Bai, Chuance Sun, Buyong Ma   +3 more
doaj   +5 more sources

An Introduction to B-Cell Epitope Mapping and In Silico Epitope Prediction [PDF]

Journal of Immunology Research, 2016
Identification of B-cell epitopes is a fundamental step for development of epitope-based vaccines, therapeutic antibodies, and diagnostic tools. Epitope-based antibodies are currently the most promising class of biopharmaceuticals. In the last decade, in-
Lenka Potocnakova, Mangesh Bhide, Lucia Borszekova Pulzova   +2 more
doaj   +6 more sources

DiscovEpi: automated whole proteome MHC-I-epitope prediction and visualization [PDF]

BMC Bioinformatics
Background Antigen presentation is a central step in initiating and shaping the adaptive immune response. To activate CD8+ T cells, pathogen-derived peptides are presented on the cell surface of antigen-presenting cells bound to major histocompatibility ...
C. Mahncke, F. Schmiedeke, S. Simm, L. Kaderali, B. M. Bröker, U. Seifert, C. Cammann   +6 more
doaj   +3 more sources

Epitope Prediction Based on Random Peptide Library Screening: Benchmark Dataset and Prediction Tools Evaluation

Molecules, 2011
Epitope prediction based on random peptide library screening has become a focus as a promising method in immunoinformatics research. Some novel software and web-based servers have been proposed in recent years and have succeeded in given test cases ...
Yanxin Huang, Hongyan Wang, Zhiqiang Ma, Yinghua Lv, Pingping Sun, Wenhan Chen   +5 more
doaj   +4 more sources

An assessment on epitope prediction methods for protozoa genomes [PDF]

BMC Bioinformatics, 2012
Background Epitope prediction using computational methods represents one of the most promising approaches to vaccine development. Reduction of time, cost, and the availability of completely sequenced genomes are key points and highly motivating regarding
Resende Daniela M, Rezende Antônio M, Oliveira Nesley JD, Batista Izabella CA, Corrêa-Oliveira Rodrigo, Reis Alexandre B, Ruiz Jeronimo C   +6 more
doaj   +7 more sources

WUREN: Whole-modal union representation for epitope prediction [PDF]

Computational and Structural Biotechnology Journal
B-cell epitope identification plays a vital role in the development of vaccines, therapies, and diagnostic tools. Currently, molecular docking tools in B-cell epitope prediction are heavily influenced by empirical parameters and require significant ...
Xiaodong Wang, Xiangrui Gao, Xuezhe Fan, Zhe Huai, Genwei Zhang, Mengcheng Yao, Tianyuan Wang, Xiaolu Huang, Lipeng Lai   +8 more
doaj   +3 more sources

Prediction of T-Cell Epitope

Journal of Pharmacological Sciences, 2007
The prevailing methods to predict T-cell epitopes are reviewed. Motif matching, matrix, support vector machine (SVM), and empirical scoring function methods are mainly reviewed; and the thermodynamic integration (TI) method using all-atom molecular ...
Hiromichi Tsurui, Takuya Takahashi
doaj   +4 more sources

Towards the prediction of non-peptidic epitopes.

PLoS Computational Biology, 2022
In-silico methods for the prediction of epitopes can support and improve workflows for vaccine design, antibody production, and disease therapy. So far, the scope of B cell and T cell epitope prediction has been directed exclusively towards peptidic ...
Paul F Zierep, Randi Vita, Nina Blazeska, Aurélien F A Moumbock, Jason A Greenbaum, Bjoern Peters, Stefan Günther   +6 more
doaj   +5 more sources

Assessing the predictive ability of computational epitope prediction methods on Fel d 1 and other allergens. [PDF]

PLoS ONE
While computational epitope prediction methods have found broad application, their use, specifically in allergy-related contexts, remains relatively less explored. This study benchmarks several publicly available epitope prediction tools, focusing on the
Hyeji Kwon, Soobon Ko, Kyungsoo Ha, Jungjoon K Lee, Yoonjoo Choi   +4 more
doaj   +2 more sources

Epitope-Evaluator: An interactive web application to study predicted T-cell epitopes.

PLoS ONE, 2022
Multiple immunoinformatic tools have been developed to predict T-cell epitopes from protein amino acid sequences for different major histocompatibility complex (MHC) alleles.
Luis Fernando Soto, David Requena, Juan Ignacio Fuxman Bass   +2 more
doaj   +4 more sources