Results 41 to 50 of about 1,625,834 (280)

Machine learning approaches for epitope prediction [PDF]

, 2008
The identification and characterization of epitopes in antigenic sequences is critical for understanding disease pathogenesis, for identifying potential autoantigens, and for designing vaccines and immune-based cancer therapies. As the number of pathogen
El-manzalawy, Yasser
core   +1 more source

Epitope-Based Specific Antibody Modification [PDF]

, 2023
Modified antibodies play essential roles in various fields, such as analysis, diagnosis, and therapy, which require modified antibodies with optimal physical and biological properties.
Saki, Horie, Kenji, Mishiro, Mio, Nishino, Inori, Domae, Mitsuo, Wakasugi, Tsukasa, Matsunaga, Munetaka, Kunishima   +6 more
core   +1 more source

Epi4Ab: a data-driven prediction model of conformational epitopes for specific antibody VH/VL families and CDRs sequences

mAbs
Antibodies recognize antigens via complementary and structurally dependent mechanisms. Therefore, inclusion of antibody inputs is crucial for accurate epitope prediction.
Nhan Dinh Tran, Krithika Subramani, Chinh Tran-To Su   +2 more
doaj   +1 more source

Development of a novel in silico docking simulation model for the fine HIV-1 cytotoxic T lymphocyte epitope mapping. [PDF]

PLoS ONE, 2012
INTRODUCTION: Class I HLA's polymorphism has hampered CTL epitope mapping with laborious experiments. Objectives are 1) to evaluate the novel in silico model in predicting previously reported epitopes in comparison with existing program, and 2) to apply ...
Masahiko Mori, Kei Matsuki, Tomoyuki Maekawa, Mari Tanaka, Busarawan Sriwanthana, Masaru Yokoyama, Koya Ariyoshi   +6 more
doaj   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

AsEP: Benchmarking Deep Learning Methods for Antibody-specific Epitope Prediction [PDF]

Epitope identification is vital for antibody design yet challenging due to the inherent variability in antibodies. While many deep learning methods have been developed for general protein binding site prediction tasks, whether they work for epitope ...
Denzler, L, Martin, A, Paige, B, Liu, C, Chen, Y   +4 more
core   +2 more sources

HLA class I restricted epitopes prediction of common tumor antigens in white and East Asian populations: Implication on antigen selection for cancer vaccine design.

PLoS ONE, 2020
Tumor antigens processed and presented by human leukocyte antigen (HLA) Class I alleles are important targets in tumor immunotherapies. Clinical trials showed that presence of CD8+ T cells specific to tumor associated antigens (TAAs) and tumor ...
Wei Hu, Meifang He, Liangping Li
doaj   +1 more source

Survival After Hematopoietic Stem Cell Transplantation in Diamond–Blackfan Anemia Syndrome: The Role of Iron Overload—A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens, Evangelia Kiakou, Lieke de Zwart, Maurizio Miano, Eduard J. van Beers, Marc Bierings, Marije Bartels   +6 more
wiley   +1 more source

PepMapper: a collaborative web tool for mapping epitopes from affinity-selected peptides. [PDF]

PLoS ONE, 2012
Epitope mapping from affinity-selected peptides has become popular in epitope prediction, and correspondingly many Web-based tools have been developed in recent years. However, the performance of these tools varies in different circumstances.
Wenhan Chen, William W Guo, Yanxin Huang, Zhiqiang Ma   +3 more
doaj   +1 more source

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source