Results 21 to 30 of about 1,625,834 (280)

DiscoTope-3.0: improved B-cell epitope prediction using inverse folding latent representations [PDF]

Frontiers in Immunology
Morten Nielsen
exaly   +2 more sources

Epitope prediction.

, 2023
(A). Linear B cell epitope prediction. Prediction in BepiPred 2.0. Residues that present a score higher than 0.46 are indicated with an E at the top of the sequence. Residues with values greater than 0.46 are colored in dark orange. (B).
Edgar Mixcoha (1786729), Rogelio Hernández-Pando (60614), Constanza Estefania Martinez-Olivares (12897260)   +2 more
core   +1 more source

Epitope-Based Specific Antibody Modifications

, 2023
Modified antibodies have essential roles in analytic, diagnostic, and therapeutic uses, and thus, these antibodies are required to have optimal physical and biological properties.
Kenji Mishiro (1910746), Munetaka Kunishima (1490335), Mitsuo Wakasugi (9303), Inori Domae (17261852), Saki Horie (17073966), Mio Nishino (17261849), Tsukasa Matsunaga (2706478)   +6 more
core   +1 more source

B-cell epitope prediction software.

, 2022
B-cell epitope prediction software.
Thajasvarie Naicker (3175269), Maritha Kasambala (9538307), Tariro L. Mduluza-Jokonya (10881499), Arthur Vengesai (6423581), Takafira Mduluza (39754), Hamlet Mutandadzi (10881496)   +5 more
core   +1 more source

Benchmark datasets of immune receptor-epitope structural complexes

BMC Bioinformatics, 2019
Background The development of accurate epitope prediction tools is important in facilitating disease diagnostics, treatment and vaccine development. The advent of new approaches making use of antibody and TCR sequence information to predict receptor ...
Swapnil Mahajan, Zhen Yan, Martin Closter Jespersen, Kamilla Kjærgaard Jensen, Paolo Marcatili, Morten Nielsen, Alessandro Sette, Bjoern Peters   +7 more
doaj   +1 more source

Computational epitope mapping of class I fusion proteins using low complexity supervised learning methods.

PLoS Computational Biology, 2022
Antibody epitope mapping of viral proteins plays a vital role in understanding immune system mechanisms of protection. In the case of class I viral fusion proteins, recent advances in cryo-electron microscopy and protein stabilization techniques have ...
Marion F S Fischer, James E Crowe, Jens Meiler   +2 more
doaj   +1 more source

The Cancer Epitope Database and Analysis Resource: A Blueprint for the Establishment of a New Bioinformatics Resource for Use by the Cancer Immunology Community

Frontiers in Immunology, 2021
Recent years have witnessed a dramatic rise in interest towards cancer epitopes in general and particularly neoepitopes, antigens that are encoded by somatic mutations that arise as a consequence of tumorigenesis.
Zeynep Koşaloğlu-Yalçın, Nina Blazeska, Hannah Carter, Hannah Carter, Morten Nielsen, Morten Nielsen, Ezra Cohen, Donald Kufe, Jose Conejo-Garcia, Jose Conejo-Garcia, Paul Robbins, Stephen P. Schoenberger, Bjoern Peters, Bjoern Peters, Alessandro Sette, Alessandro Sette   +15 more
doaj   +1 more source

Conformational epitope matching and prediction based on protein surface spiral features

BMC Genomics, 2021
Background A conformational epitope (CE) is composed of neighboring amino acid residues located on an antigenic protein surface structure. CEs bind their complementary paratopes in B-cell receptors and/or antibodies. An effective and efficient prediction
Ying-Tsang Lo, Tao-Chuan Shih, Tun-Wen Pai, Li-Ping Ho, Jen-Leih Wu, Hsin-Yiu Chou   +5 more
doaj   +1 more source

CEP: a conformational epitope prediction server [PDF]

Nucleic Acids Research, 2005
CEP server (http://bioinfo.ernet.in/cep.htm) provides a web interface to the conformational epitope prediction algorithm developed in-house. The algorithm, apart from predicting conformational epitopes, also predicts antigenic determinants and sequential epitopes.
Urmila Kulkarni-Kale, Shriram Bhosle, Ashok S. Kolaskar   +2 more
openaire   +3 more sources

ISOTOPE: ISOform-guided prediction of epiTOPEs in cancer [PDF]

PLOS Computational Biology, 2020
Immunotherapies provide effective treatments for previously untreatable tumors and identifying tumor-specific epitopes can help elucidate the molecular determinants of therapy response. Here, we describe a pipeline, ISOTOPE (ISOform-guided prediction of epiTOPEs In Cancer), for the comprehensive identification of tumor-specific ...
Juan L. Trincado, Marina Reixachs-Solé, Judith Pérez-Granado, Tim Fugmann, Ferran Sanz, Jun Yokota, Eduardo Eyras   +6 more
openaire   +6 more sources