Fundamentals and Methods for T- and B-Cell Epitope Prediction [PDF]
Journal of Immunology Research, 2017 Adaptive immunity is mediated by T- and B-cells, which are immune cells capable of developing pathogen-specific memory that confers immunological protection.
Jose L. Sanchez-Trincado +2 more
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Improved Antibody‐Specific Epitope Prediction Using AlphaFold and AbAdapt** [PDF]
ChemBioChem, 2022 Zichang Xu, Daron Standley
exaly +2 more sources
BepiPred ‐3.0: Improved B‐cell epitope prediction using protein language models [PDF]
Protein Science, 2022 Joakim Nøddeskov Clifford
exaly +2 more sources
T Cell Epitope Prediction and Its Application to Immunotherapy [PDF]
Frontiers in Immunology, 2021 Annie Borch +2 more
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Immunoinformatics Approach for Epitope-Based Vaccine Design: Key Steps for Breast Cancer Vaccine
Diagnostics, 2022 Vaccines are an upcoming medical intervention for breast cancer. By targeting the tumor antigen, cancer vaccines can be designed to train the immune system to recognize tumor cells. Therefore, along with technological advances, the vaccine design process
Aisyah Fitriannisa Prawiningrum +2 more
doaj +1 more source
Geometric Epitope and Paratope Prediction
Bioinformatics, 2023 Abstract Antibody-antigen interactions play a crucial role in identifying and neutralizing harmful foreign molecules. In this paper, we investigate the optimal representation for predicting the binding sites in the two molecules and emphasize the importance of geometric information.
Marco Pegoraro +4 more
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Conformational B-cell epitope prediction on antigen protein structures: a review of current algorithms and comparison with common binding site prediction methods. [PDF]
PLoS ONE, 2013 Accurate prediction of B-cell antigenic epitopes is important for immunologic research and medical applications, but compared with other bioinformatic problems, antigenic epitope prediction is more challenging because of the extreme variability of ...
Bo Yao +3 more
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EpiBuilder: A Tool for Assembling, Searching, and Classifying B-Cell Epitopes
Bioinformatics and Biology Insights, 2022 Epitopes are portions of a protein that are recognized by antibodies. These small amino acid sequences represent a significant breakthrough in a branch of bioinformatics called immunoinformatics.
Renato Simões Moreira +4 more
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BepiTBR: T-B reciprocity enhances B cell epitope prediction
iScience, 2022 Summary: The ability to predict B cell epitopes is critical for biomedical research and many clinical applications. Investigators have observed the phenomenon of T-B reciprocity, in which candidate B cell epitopes with nearby CD4+ T cell epitopes have ...
James Zhu +5 more
doaj +1 more source
B-Cell Epitope Discovery: The First Protein Flexibility-Based Algorithm – Zika Virus Conserved Epitope Demonstration [PDF]
, 2020 Antibody-antigen interaction – at antigenic local environments called B-cell epitopes – is a prominent mechanism for neutralization of infection. Effective mimicry, and display, of B-cell epitopes is key to vaccine design.
Peter J., Ortoleva +2 more
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