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COVID-19 Vaccine Design: The Janus Face of Immune Enhancement
Nature Reviews Immunology, 2020 Previous work on severe acute respiratory syndrome coronavirus (SARS-CoV) vaccines identified cellular immunopathology and antibody-dependent enhancement as potential safety issues.
Peter J. Hotez +2 more
exaly +2 more sources
Immune Cell Signaling in Feline Infectious Peritonitis Virus Infection and Implications for Vaccine Design [PDF]
VaccinesFeline infectious peritonitis virus (FIPV) remains one of the most challenging viral diseases in veterinary medicine, largely owing to the absence of a consistently effective and safe vaccine.
Hye-Mi Lee
doaj +2 more sources
Artificial intelligence for coordinating vaccine design, antiviral discovery, and real-world monitoring in the era of emerging and endemic viral threats [PDF]
Frontiers in PharmacologyVaccine development has traditionally been a lengthy and resource-intensive process, often struggling to keep pace with rapidly emerging infectious threats.
Adewunmi Akingbola +9 more
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mAbs, 2021 Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infections resulting in medical intervention and hospitalizations during infancy and early childhood, and vaccination against RSV remains a public health priority.
Wayne Harshbarger +6 more
doaj +1 more source
In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms
Cellular & Molecular Immunology, 2023 Members of the coronaviridae family are endemic to human populations and have caused several epidemics and pandemics in recent history. In this review, we will discuss the feasibility of and progress toward the ultimate goal of creating a pan-coronavirus
S. Cankat, M. U. Demael, Leo Swadling
semanticscholar +1 more source
Nature Machine Intelligence, 2022 Human leukocyte antigen (HLA) can recognize and bind foreign peptides to present them to specialized immune cells, then initiate an immune response. Computational prediction of the peptide and HLA (pHLA) binding can speed up immunogenic peptide screening
Yanyi Chu +11 more
semanticscholar +1 more source
Rise of the RNA machines – self-amplification in mRNA vaccine design
Trends in Biotechnology, 2023 mRNA vaccines have won the race for early COVID-19 vaccine approval, yet improvements are necessary to retain this leading role in combating infectious diseases.
J. D. Comes +2 more
semanticscholar +1 more source
Glycan masking in vaccine design: Targets, immunogens and applications
Frontiers in Immunology, 2023 Glycan masking is a novel technique in reverse vaccinology in which sugar chains (glycans) are added on the surface of immunogen candidates to hide regions of low interest and thus focus the immune system on highly therapeutic epitopes.
Cristina E. Martina, J. Crowe, J. Meiler
semanticscholar +1 more source
Recent Developments in Vaccine Design: From Live Vaccines to Recombinant Toxin Vaccines
Toxins, 2023 Vaccines are one of the most effective strategies to prevent pathogen-induced illness in humans. The earliest vaccines were based on live inoculations with low doses of live or related pathogens, which carried a relatively high risk of developing the ...
Sonal Gupta, S. Pellett
semanticscholar +1 more source
Machine Learning-Assisted Screening of Herbal Medicine Extracts as Vaccine Adjuvants
Frontiers in Immunology, 2022 Adjuvants are important vaccine components, composed of a variety of chemical and biological materials that enhance the vaccine antigen-specific immune responses by stimulating the innate immune cells in both direct and indirect manners to produce a ...
Kou Hioki +18 more
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