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Immune Cell Signaling in Feline Infectious Peritonitis Virus Infection and Implications for Vaccine Design [PDF]

Vaccines
Feline infectious peritonitis virus (FIPV) remains one of the most challenging viral diseases in veterinary medicine, largely owing to the absence of a consistently effective and safe vaccine.
Hye-Mi Lee
doaj   +2 more sources

Artificial intelligence for coordinating vaccine design, antiviral discovery, and real-world monitoring in the era of emerging and endemic viral threats [PDF]

Frontiers in Pharmacology
Vaccine development has traditionally been a lengthy and resource-intensive process, often struggling to keep pace with rapidly emerging infectious threats.
Adewunmi Akingbola, Abiodun Adegbesan, Olajumoke Adewole, Kehinde O. Adebiyi, Akpevwe Emmanuel Benson, Olajide Ojo, Jessica Otumara Urowoli, Opeyemi Joshua Alabi, Oluwaremilekun Juliet Ojeriakhi, Mayowa Shekoni   +9 more
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Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein

mAbs, 2021
Respiratory syncytial virus (RSV) is the most common cause of acute lower respiratory tract infections resulting in medical intervention and hospitalizations during infancy and early childhood, and vaccination against RSV remains a public health priority.
Wayne Harshbarger, Priyanka D. Abeyrathne, Sai Tian, Ying Huang, Sumana Chandramouli, Matthew James Bottomley, Enrico Malito   +6 more
doaj   +1 more source

Machine Learning-Assisted Screening of Herbal Medicine Extracts as Vaccine Adjuvants

Frontiers in Immunology, 2022
Adjuvants are important vaccine components, composed of a variety of chemical and biological materials that enhance the vaccine antigen-specific immune responses by stimulating the innate immune cells in both direct and indirect manners to produce a ...
Kou Hioki, Kou Hioki, Tomoya Hayashi, Tomoya Hayashi, Yayoi Natsume-Kitatani, Kouji Kobiyama, Kouji Kobiyama, Burcu Temizoz, Burcu Temizoz, Hideo Negishi, Hitomi Kawakami, Hiroyuki Fuchino, Etsushi Kuroda, Cevayir Coban, Cevayir Coban, Nobuo Kawahara, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +18 more
doaj   +1 more source

Susceptibility Analysis in Several Mouse Strains Reveals Robust T-Cell Responses After Mycoplasma pneumoniae Infection in DBA/2 Mice

Frontiers in Cellular and Infection Microbiology, 2021
Mycoplasma pneumoniae (Mp) is a highly contagious respiratory pathogen responsible for human community-acquired pneumonia. The number of antibiotic-resistant Mp strains is increasing; therefore, to develop novel therapeutics, it is crucial to precisely ...
Shigeyuki Tamiya, Shigeyuki Tamiya, Shigeyuki Tamiya, Eisuke Yoshikawa, Eisuke Yoshikawa, Eisuke Yoshikawa, Koichiro Suzuki, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka   +11 more
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Considerations of CD8+ T Cells for Optimized Vaccine Strategies Against Respiratory Viruses

Frontiers in Immunology, 2022
The primary goal of vaccines that protect against respiratory viruses appears to be the induction of neutralizing antibodies for a long period. Although this goal need not be changed, recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...
Toshiro Hirai, Toshiro Hirai, Toshiro Hirai, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka   +6 more
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Effects of hypoxia on antigen presentation and T cell-based immune recognition of HPV16-transformed cells

Frontiers in Immunology, 2022
Attempts to develop a therapeutic vaccine against human papillomavirus (HPV)-induced malignancies have mostly not been clinically successful to date.
Nitya Mohan, Nitya Mohan, Nitya Mohan, Kathrin Wellach, Kathrin Wellach, Kathrin Wellach, Ceren Özerdem, Ceren Özerdem, Nisha Veits, Nisha Veits, Jonas D. Förster, Jonas D. Förster, Jonas D. Förster, Sophia Foehr, Sophia Foehr, Maria Bonsack, Maria Bonsack, Angelika B. Riemer, Angelika B. Riemer   +18 more
doaj   +1 more source

Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail

Retrovirology, 2018
Background HIV-1 Env gp160 is cleaved to form gp120 and gp41 and the functional HIV-1 Env is a trimer of non-covalently associated heterodimeric subunits, gp120 and gp41.
Sweety Samal, Supratik Das, Saikat Boliar, Huma Qureshi, Tripti Shrivastava, Naresh Kumar, Sandeep Goswami, Manish Bansal, Bimal K. Chakrabarti   +8 more
doaj   +1 more source

Structure-based design of stabilized recombinant influenza neuraminidase tetramers

Nature Communications, 2022
Influenza virus neuraminidase (NA) is a drug target and a potential vaccine antigen. Here, the authors provide a detailed analysis of the conformational stability of NA, and show how expression and stability of recombinant NA antigens can be strengthened
Daniel Ellis, Julia Lederhofer, Oliver J. Acton, Yaroslav Tsybovsky, Sally Kephart, Christina Yap, Rebecca A. Gillespie, Adrian Creanga, Audrey Olshefsky, Tyler Stephens, Deleah Pettie, Michael Murphy, Claire Sydeman, Maggie Ahlrichs, Sidney Chan, Andrew J. Borst, Young-Jun Park, Kelly K. Lee, Barney S. Graham, David Veesler, Neil P. King, Masaru Kanekiyo   +21 more
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Inducing Immunity Where It Matters: Orthotopic HPV Tumor Models and Therapeutic Vaccinations

Frontiers in Immunology, 2020
Anogenital and oropharyngeal cancers caused by human papillomavirus (HPV) infections account for 4.5% of all cancer cases worldwide. So far, only the initial infection with selected high-risk types can be prevented by prophylactic vaccination.
Samantha Zottnick, Samantha Zottnick, Samantha Zottnick, Alessa L. Voß, Alessa L. Voß, Angelika B. Riemer, Angelika B. Riemer   +6 more
doaj   +1 more source