Results 21 to 30 of about 26,123,489 (353)

COVID-19 vaccine design using reverse and structural vaccinology, ontology-based literature mining and machine learning

Briefings Bioinform., 2022
Rational vaccine design, especially vaccine antigen identification and optimization, is critical to successful and efficient vaccine development against various infectious diseases including coronavirus disease 2019 (COVID-19).
A. Huffman, E. Ong, J. Hur, Adonis D'Mello, H. Tettelin, Y. He   +5 more
semanticscholar   +1 more source

Cell surface ectodomain integrity of a subset of functional HIV-1 envelopes is dependent on a conserved hydrophilic domain containing region in their C-terminal tail

Retrovirology, 2018
Background HIV-1 Env gp160 is cleaved to form gp120 and gp41 and the functional HIV-1 Env is a trimer of non-covalently associated heterodimeric subunits, gp120 and gp41.
Sweety Samal, Supratik Das, Saikat Boliar, Huma Qureshi, Tripti Shrivastava, Naresh Kumar, Sandeep Goswami, Manish Bansal, Bimal K. Chakrabarti   +8 more
doaj   +1 more source

In-Silico Vaccine Design Based on a Novel Vaccine Candidate Against Infections Caused by Acinetobacter baumannii

International Journal of Peptide Research and Therapeutics, 2021
Acinetobacter baumannii is notorious for causing serious infections of the skin, lungs, soft tissues, bloodstream, and urinary tract. Despite the overwhelming information available so far, there has still been no approved vaccine in the market to prevent
K. Khalid, Sidra Irum, S. Ullah, S. Andleeb   +3 more
semanticscholar   +1 more source

The Correlated Beta Dose Optimisation Approach: Optimal Vaccine Dosing Using Mathematical Modelling and Adaptive Trial Design [PDF]

, 2022
Mathematical modelling methods and adaptive trial design are likely to be effective for optimising vaccine dose but are not yet commonly used. This may be due to uncertainty with regard to the correct choice of parametric model for dose-efficacy or dose ...
Benest, John, Evans, Thomas G, White, Richard G, White, Richard G., Thomas G. Evans, Evans, Thomas G., Sophie Rhodes, Rhodes, Sophie, John Benest, Richard G. White   +9 more
core   +1 more source

Structure-based design of stabilized recombinant influenza neuraminidase tetramers

Nature Communications, 2022
Influenza virus neuraminidase (NA) is a drug target and a potential vaccine antigen. Here, the authors provide a detailed analysis of the conformational stability of NA, and show how expression and stability of recombinant NA antigens can be strengthened
Daniel Ellis, Julia Lederhofer, Oliver J. Acton, Yaroslav Tsybovsky, Sally Kephart, Christina Yap, Rebecca A. Gillespie, Adrian Creanga, Audrey Olshefsky, Tyler Stephens, Deleah Pettie, Michael Murphy, Claire Sydeman, Maggie Ahlrichs, Sidney Chan, Andrew J. Borst, Young-Jun Park, Kelly K. Lee, Barney S. Graham, David Veesler, Neil P. King, Masaru Kanekiyo   +21 more
doaj   +1 more source

Inducing Immunity Where It Matters: Orthotopic HPV Tumor Models and Therapeutic Vaccinations

Frontiers in Immunology, 2020
Anogenital and oropharyngeal cancers caused by human papillomavirus (HPV) infections account for 4.5% of all cancer cases worldwide. So far, only the initial infection with selected high-risk types can be prevented by prophylactic vaccination.
Samantha Zottnick, Samantha Zottnick, Samantha Zottnick, Alessa L. Voß, Alessa L. Voß, Angelika B. Riemer, Angelika B. Riemer   +6 more
doaj   +1 more source

An Immunoinformatics Approach to Design a Potent Multi-Epitope Vaccine against Asia-1 Genotype of Crimean–Congo Haemorrhagic Fever Virus Using the Structural Glycoproteins as a Target

Vaccines, 2022
Crimean–Congo haemorrhagic fever (CCHF), caused by Crimean–Congo haemorrhagic fever virus (CCHFV), is a disease of worldwide importance (endemic yet not limited to Asia, Middle East, and Africa) and has triggered several outbreaks amounting to a case ...
Syed Zawar Shah, Basit Jabbar, Muhammad Usman Mirza, Muhammad Waqas, Shahkaar Aziz, Sobia Ahsan Halim, Amjad Ali, Shazia Rafique, Muhammad Idrees, Asaad Khalid, Ashraf N. Abdalla, Ajmal Khan, Ahmed Al-Harrasi   +12 more
doaj   +1 more source

Immune imprinting and SARS-CoV-2 vaccine design

Trends in immunology, 2021
Reformulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines with variant strains is being pursued to combat the global surge in infections.
A. Wheatley, A. Fox, Hyon-Xhi Tan, J. Juno, M. Davenport, K. Subbarao, S. Kent   +6 more
semanticscholar   +1 more source

Heterogeneity in malaria exposure and vaccine response: implications for the interpretation of vaccine efficacy trials. [PDF]

, 2010
BACKGROUND: Phase III trials of the malaria vaccine, RTS, S, are now underway across multiple sites of varying transmission intensity in Africa. Heterogeneity in exposure, vaccine response and waning of efficacy may bias estimates of vaccine efficacy ...
Michael T White, Jamie T Griffin, Azra C Ghani, Drakeley, Chris J, Ghani Azra C, Ghani, Azra C, Griffin, Jamie T, Drakeley Chris J, White, Michael T, White Michael T, Griffin Jamie T, Chris J Drakeley   +11 more
core   +1 more source

Effectiveness and safety of injectable human papilloma virus vaccine administered as eyedrops

, 2023
Mucosal vaccines have the advantages of ease of administration and the induction of strong mucosal immunity and a systemic immune response. Recently, the eye mucosa has been shown to be an effective and safe alternative vaccination route against ...
윤상철, 서경률, 이지혜
core   +1 more source