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Designing a vaccine for tuberculosis [PDF]
BMJ, 1996 Tuberculosis is a disease of superlatives. Mycobacterium tuberculosis causes more deaths annually than any other infectious agent.1 Globally, it is one of the major pathogens associated with HIV disease.1 The tuberculosis vaccine, BCG, has been given to more people than any other vaccine.2 3 However, although this vaccine confers clear benefit against ...
A S, Malin, D B, Young
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Domains and Functions of Spike Protein in SARS-Cov-2 in the Context of Vaccine Design
Viruses, 2021 The spike protein in SARS-CoV-2 (SARS-2-S) interacts with the human ACE2 receptor to gain entry into a cell to initiate infection. Both Pfizer/BioNTech’s BNT162b2 and Moderna’s mRNA-1273 vaccine candidates are based on stabilized mRNA encoding prefusion ...
X. Xia
semanticscholar +1 more source
Nucleic Acids Res., 2021 Vaccination is one of the most significant inventions in medicine. Reverse vaccinology (RV) is a state-of-the-art technique to predict vaccine candidates from pathogen's genome(s).
E. Ong +8 more
semanticscholar +1 more source
SARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness
Nature, 2020 A vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is needed to control the coronavirus disease 2019 (COVID-19) global pandemic.
K. Corbett +61 more
semanticscholar +1 more source
Principles and practical applications of structure-based vaccine design
Current Opinion in Immunology, 2022 Viral proteins fold into a variety of structures as they perform their functions. Structure-based vaccine design aims to exploit knowledge of an antigen’s architecture to stabilize it in a vulnerable conformation.
P. O. Byrne, J. McLellan
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Immunoinformatics Approach for Epitope-Based Vaccine Design: Key Steps for Breast Cancer Vaccine
Diagnostics, 2022 Vaccines are an upcoming medical intervention for breast cancer. By targeting the tumor antigen, cancer vaccines can be designed to train the immune system to recognize tumor cells. Therefore, along with technological advances, the vaccine design process
A. F. Prawiningrum +2 more
semanticscholar +1 more source
Frontiers in Cellular and Infection Microbiology, 2021 Mycoplasma pneumoniae (Mp) is a highly contagious respiratory pathogen responsible for human community-acquired pneumonia. The number of antibiotic-resistant Mp strains is increasing; therefore, to develop novel therapeutics, it is crucial to precisely ...
Shigeyuki Tamiya +11 more
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Current Opinion in Immunology, 2022 Despite the extraordinary speed and success in SARS-Cov-2 vaccine development, the emergence of variants of concern perplexed the vaccine development community. Neutralizing antibodies waned antibodies waned and were evaded by viral variants, despite the
C. Britto, G. Alter
semanticscholar +1 more source
Considerations of CD8+ T Cells for Optimized Vaccine Strategies Against Respiratory Viruses
Frontiers in Immunology, 2022 The primary goal of vaccines that protect against respiratory viruses appears to be the induction of neutralizing antibodies for a long period. Although this goal need not be changed, recent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...
Toshiro Hirai +6 more
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Frontiers in Immunology, 2022 Attempts to develop a therapeutic vaccine against human papillomavirus (HPV)-induced malignancies have mostly not been clinically successful to date.
Nitya Mohan +18 more
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