Results 41 to 50 of about 26,123,489 (353)

Lipid Nanoparticles Potentiate CpG-Oligodeoxynucleotide-Based Vaccine for Influenza Virus

Frontiers in Immunology, 2020
Current influenza vaccines are generally effective against highly similar (homologous) strains, but their effectiveness decreases markedly against antigenically mismatched (heterologous) strains. One way of developing a universal influenza vaccine with a
Seiki Shirai, Seiki Shirai, Meito Shibuya, Meito Shibuya, Atsushi Kawai, Atsushi Kawai, Shigeyuki Tamiya, Shigeyuki Tamiya, Lisa Munakata, Daiki Omata, Ryo Suzuki, Taiki Aoshi, Taiki Aoshi, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka   +16 more
doaj   +1 more source

Exploring whole proteome to contrive multi-epitope-based vaccine for NeoCoV: An immunoinformtics and in-silico approach

Frontiers in Immunology, 2022
Neo-Coronavirus (NeoCoV) is a novel Betacoronavirus (β-CoVs or Beta-CoVs) discovered in bat specimens in South Africa during 2011. The viral sequence is highly similar to Middle East Respiratory Syndrome, particularly that of structural proteins.
Shahkaar Aziz, Muhammad Waqas, Muhammad Waqas, Sobia Ahsan Halim, Amjad Ali, Aqib Iqbal, Maaz Iqbal, Ajmal Khan, Ahmed Al-Harrasi   +8 more
doaj   +1 more source

cGAMP the travelling messenger

Frontiers in Immunology, 2023
2’3’-cGAMP is a key molecule in the cGAS-STING pathway. This cyclic dinucleotide is produced by the cytosolic DNA sensor cGAS in response to the presence of aberrant dsDNA in the cytoplasm which is associated with microbial invasion or cellular damage. 2’
Henry T. W. Blest, Lise Chauveau
doaj   +1 more source

The rational design of vaccines

Drug Discovery Today, 2005
This review provides an insight into the various opportunities for vaccine intervention, analysis of strategies for vaccine development, vaccine ability to modulate immune responses and resultant rational vaccine design. In addition, wider aspects are considered, such as biotechnological advances, advances in immunological understanding and host ...
Bramwell, Vincent W., Perrie, Yvonne
openaire   +2 more sources

Viroinformatics investigation of B-cell epitope conserved region in SARS-CoV-2 lineage B.1.1.7 isolates originated from Indonesia to develop vaccine candidate against COVID-19 [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2021
Context: SARS-CoV-2, a member of family Coronaviridae and the causative agent of COVID-19, is a virus which is transmitted to human and other mammals. Aims: To analyze the B-cell epitope conserved region and viroinformatics-based study of the SARS-CoV-
Arif N. M. Ansori, Reviany V. Nidom, Muhammad K. J. Kusala, Setyarina Indrasari, Irine Normalina, Astria N. Nidom, Balqis Afifah, Kartika B. Sari, Nor L. Ramadhaniyah, Mohammad Y. Alamudi, Umi Cahyaningsih, Kuncoro P. Santoso, Heri Kuswanto, Chairul A. Nidom   +13 more
doaj  

Architects of folding, editors of immunity: the strategic use of N-glycans in vaccine design [PDF]

Frontiers in Immunology
Sofia Orioli, Tommy Idrovo-Hidalgo, Tommy Idrovo-Hidalgo, Maria de los Angeles Martinez Saucedo, Maria de los Angeles Martinez Saucedo, Cecilia D’Alessio, Cecilia D’Alessio   +6 more
doaj   +2 more sources

Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools

Frontiers in Immunology, 2020
Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using computational tools. Tools that facilitate the in silico prediction of immune response to biothreats, emerging infectious diseases, and cancers can ...
Anne Searls De Groot, L. Moise, Frances E. Terry, A. Gutiérrez, P. Hindocha, Guilhem Richard, D. Hoft, T. Ross, A. Noe, Yoshimasa Takahashi, V. Kotraiah, S. Silk, C. Nielsen, A. Minassian, R. Ashfield, Matthew Ardito, S. Draper, W. Martin   +17 more
semanticscholar   +1 more source

Vaccination: A durable design [PDF]

Nature, 2012
Vaccines on the market aren't practical for the developing world — where cervical cancer hits hardest — but researchers are trying to make ones that are.
openaire   +2 more sources

COVID-19 vaccine development pipeline

, 2020
A COVID-19 vaccine development tracker, developed by the Vaccine Centre at the London School of Hygiene & Tropical Medicine, that follows COVID-19 vaccine candidates as they progress through the development ...
Vaccine Centre
core   +3 more sources

Computational biology and artificial intelligence in mRNA vaccine design for cancer immunotherapy

Frontiers in Cellular and Infection Microbiology
Messenger RNA (mRNA) vaccines offer an adaptable and scalable platform for cancer immunotherapy, requiring optimal design to elicit a robust and targeted immune response.
Saber Imani, Xiao-Yan Li, Keyi Chen, M. Maghsoudloo, Parham Jabbarzadeh Kaboli, Mehrdad Hashemi, Saloomeh Khoushab, Xiao-Ping Li   +7 more
semanticscholar   +1 more source