Results 51 to 60 of about 9,828,326 (308)

Preclinical development of a replication-competent vesicular stomatitis virus-based Lassa virus vaccine candidate advanced into human clinical trialsResearch in context

EBioMedicine
Summary: Background: Lassa fever (LF) is a zoonotic haemorrhagic disease caused by Lassa virus (LASV), which is endemic in West African countries. The multimammate rat is the main animal reservoir and its geographic range is expected to expand due to ...
Christopher L. Cooper, Gavin Morrow, Maoli Yuan, Thomas S. Postler, Maxwell L. Neal, Robert W. Cross, Courtney Woolsey, Krystle N. Agans, Viktoriya Borisevich, Ryan P. McNamara, Caroline Atyeo, Vicky Roy, Daritza Germosen, Fuxiang Hou, Shui L. Li, Lucia Reiserova, Yesle Choi, Aaron Wilson, Denise Wagner, Olivia Wallace-Selman, Alexei Carpov, Fuqiang Geng, Deborah J. Frederick, Joanne DeStefano, Anne M. Ercolini, Adrian S. Enriquez, Kathryn M. Hastie, Suzane Ramos da Silva, Eddy Sayeed, John W. Coleman, Andrew Kilianski, Galit Alter, Erica Ollmann Saphire, John D. Aitchison, Thomas W. Geisbert, Swati B. Gupta, Mark B. Feinberg, Christopher L. Parks   +37 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Exploring computational approaches to design mRNA Vaccine against vaccinia and Mpox viruses

Immunity, Inflammation and Disease
Background Messenger RNA (mRNA) vaccines emerged as a powerful tool in the fight against infections. Unlike traditional vaccines, this unique type of vaccine elicits robust and persistent innate and humoral immune response with a unique host cell ...
Elijah K. Oladipo, Olanrewaju D. Oyelakin, Abdulsamad O. Aiyelabegan, Elizabeth O. Olajide, Victoria O. Olatayo, Kaothar P. Owolabi, Yewande B. Shittu, Rhoda O. Olugbodi, Hezekiah A. Ajala, Raji A. Rukayat, Deborah O. Olayiwola, Boluwatife A. Irewolede, Esther M. Jimah, Julius K. Oloke, Taiwo O. Ojo, Olumide F. Ajani, Bamidele A. Iwalokun, Olatunji M. Kolawole, Olumuyiwa E. Ariyo, Daniel A. Adediran, Seun E. Olufemi, Helen Onyeaka   +21 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Cost-effectiveness analysis of the implementation of a National Immunization Program for rotavirus vaccination in a country with a low rotavirus gastroenteritis-related mortality: A South Korean study [PDF]

, 2019
Rotavirus is a leading cause of severe gastroenteritis among children younger than 5 years in South Korea. Two rotavirus vaccines (RVs), pentavalent human-bovine reassortant vaccine (Rotateq®; RV5) and attenuated human strain originated monovalent ...
김지홍, 김동수
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design

eLife, 2017
Pathogens rely on proteins embedded on their surface to perform tasks essential for host infection. These obligatory structures exposed to the host immune system provide important targets for rational vaccine design.
Ching-Lin Hsieh, Christopher P Ptak, Andrew Tseng, Igor Massahiro de Souza Suguiura, Sean P McDonough, Tepyuda Sritrakul, Ting Li, Yi-Pin Lin, Richard E Gillilan, Robert E Oswald, Yung-Fu Chang   +10 more
doaj   +1 more source

Genomic Sequencing and Analysis of Eight Camel-Derived Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Isolates in Saudi Arabia

Viruses, 2020
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans; the second-largest and most deadly outbreak to date occurred in Saudi Arabia.
Badr M. Al-Shomrani, Manee M. Manee, Sultan N. Alharbi, Mussad A. Altammami, Manal A. Alshehri, Majed S. Nassar, Muhammed A. Bakhrebah, Mohamed B. Al-Fageeh   +7 more
doaj   +1 more source

Systems biology in vaccine design [PDF]

Microbial Biotechnology, 2011
Summary Vaccines are the most effective tools to prevent infectious diseases and to minimize their impact on humans or animals. Despite the successful development of vaccines that are able to elicit potent and protective immune responses, the majority of vaccines have been so far developed empirically and ...
Six, Adrien, Bellier, Bertrand, Thomas‐Vaslin, Véronique, Klatzmann, David   +3 more
openaire   +2 more sources