Results 61 to 70 of about 26,123,489 (353)

An in silico deep learning approach to multi-epitope vaccine design: a SARS-CoV-2 case study

Scientific Reports, 2020
The rampant spread of COVID-19, an infectious disease caused by SARS-CoV-2, all over the world has led to over millions of deaths, and devastated the social, financial and political entities around the world. Without an existing effective medical therapy,
Zi-Kun Yang, P. Bogdan, Shahin Nazarian
semanticscholar   +1 more source

Designing Meningitis Vaccines

Journal of the Royal College of Physicians of London, 2000
Conjugate polysaccharide vaccines are a recent intervention to combat the relative inability of young children to mount an effective immune response against encapsulated bacteria, especially Haemophilus influenzae (Hib), Neisseria meningitidis (Nm) and Streptococcus pneumoniae (Sp).
J P, Buttery, E R, Moxon
openaire   +2 more sources

Utilizing Immunoinformatics for mRNA Vaccine Design against Influenza D Virus

BioMedInformatics
Background: Influenza D Virus (IDV) presents a possible threat to animal and human health, necessitating the development of effective vaccines. Although no human illness linked to IDV has been reported, the possibility of human susceptibility to ...
Elijah Kolawole Oladipo, Stephen Feranmi Adeyemo, Modinat Wuraola Akinboade, Temitope Michael Akinleye, Kehinde Favour Siyanbola, Precious Ayomide Adeogun, Victor Michael Ogunfidodo, Christiana Adewumi Adekunle, Olubunmi Ayobami Elutade, Esther Eghogho Omoathebu, Blessing Oluwatunmise Taiwo, Elizabeth Olawumi Akindiya, Lucy Ochola, Helen Onyeaka   +13 more
doaj   +1 more source

Harnessing computational immunology to design targeted subunit vaccines for infectious bursal disease in poultry

Frontiers in Bioinformatics
IntroductionInfectious bursal disease (IBD), caused by the infectious bursal disease Q8 virus (IBDV), is a highly contagious disease in young chickens, leading to immunosuppression with great economic importance.
Elijah Kolawole Oladipo, Elijah Kolawole Oladipo, Elijah Kolawole Oladipo, Stephen Feranmi Adeyemo, Ayomiposi Isaiah Oshoneye, Hannah Blessing Akintola, Bolatito Islam Elegbede, Tobiloba Uren Ayoomoba, Dorcas Ayomide Atilade, Omolara Omoboye Adegboye, Abuoma Elizabeth Ejikeme, Abuoma Elizabeth Ejikeme, Chris Olamide Balogun, Kehinde Abolade Aderibigbe, Possible Okikiola Popoola, Victoria Ajike Alabi, Boluwatife Ayobami Irewolede, Gbemi Henry Ano-Edward, Ademola Olabode Ayeleso, Ademola Olabode Ayeleso, Helen Onyeaka   +20 more
doaj   +1 more source

Cationic Nanostructures for Vaccines Design [PDF]

Biomimetics, 2020
Subunit vaccines rely on adjuvants carrying one or a few molecular antigens from the pathogen in order to guarantee an improved immune response. However, to be effective, the vaccine formulation usually consists of several components: an antigen carrier, the antigen, a stimulator of cellular immunity such as a Toll-like Receptors (TLRs) ligand, and a ...
Ana Maria Carmona-Ribeiro, Yunys Pérez-Betancourt   +1 more
openaire   +3 more sources

A 5-year follow-up of antibody response in children vaccinated with single dose of live attenuated SA14-14-2 Japanese encephalitis vaccine: immunogenicity and anamnestic responses

, 2008
Out of 98 subjects who had participated in the 2000 JE vaccination campaign, 69 people were enrolled in the tests of 2004 and 2005 for the evaluation of long term immune response of a single dose of live attenuated SA14-14-2 JE vaccine.
오희철
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Enhanced Radiation Sensitivity of Human Papillomavirus-Driven Head and Neck Cancer: Focus on Immunological Aspects

Frontiers in Immunology, 2019
Head and neck squamous cell carcinomas (HNSCC), emerging in the mucosa of the upper aerodigestive tract, are associated with either the classical risk factors, tobacco and alcohol consumption, or with infections with high-risk types of the human ...
Mine Özcan-Wahlbrink, Mine Özcan-Wahlbrink, Christoph Schifflers, Christoph Schifflers, Christoph Schifflers, Angelika B. Riemer, Angelika B. Riemer   +6 more
doaj   +1 more source

Single dose of SA 14-14-2 vaccine provides long-term protection against Japanese encephalitis: A case-control study in Nepalese children 5 years after immunization

, 2007
In July 1999, a single dose of live-attenuated SA 14-14-2 Japanese encephalitis (JE) vaccine was administered to children living in the Bardiya, Banke and Kailali districts of Nepal.
오희철, 남정모
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source