Results 81 to 90 of about 9,828,326 (308)

Translating Observations From Leishmanization Into Non-Living Vaccines: The Potential of Dendritic Cell-Based Vaccination Strategies Against Leishmania

Frontiers in Immunology, 2018
Leishmaniasis is a health-threatening vector-borne disease in almost 90 different countries. While a prophylactic human vaccine is not yet available, the fact that recovery from leishmaniasis establishes lifelong immunity against secondary infection ...
Negar Seyed, Nathan C. Peters, Sima Rafati   +2 more
doaj   +1 more source

First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. [PDF]

, 2011
BACKGROUND\ud \ud An ongoing phase 3 study of the efficacy, safety, and immunogenicity of candidate malaria vaccine RTS,S/AS01 is being conducted in seven African countries.\ud \ud METHODS\ud \ud From March 2009 through January 2011, we enrolled 15,460 ...
Machera, Francisca, Abdulla, Salim, Sillman, Marla, Maingi, Charity, Aide, Pedro, Hamad, AS, Sambian, D, Kremsner, Peter Gottfried, Mordmüller, B, Conzelmann, Cornelia, Maingi, C, Sylverken, J, Adjei, George, Sandrine, Y, Abdul, Omari, Owusu-Ofori, R, Drakeley, C, Ansong, D, Leach, Amanda, Urassa, AM, Radford, A, Kayan, K, Methogo, Barbara Gaelle Nfono Ondo, Carter, T, Bejon, Philip, Gondi, Stacey, Chome, Nelecy, Akoo, P, Doucka, Yannick, Aponte, John J, Guerra, Yolanda, Aponte, JJ, Valea, I, Chandramohan, Daniel, null null, Alonso, P, Jones, David, Liheluka, Edwin, Sillman, M, Loucq, Christian, Malabeja, A, Omoto, Jackton, Agnandji, ST, Nyakuipa, Dalitso, Quelhas, D, Flamen, Arnaud, Jongert, Erik, Ahmed, S, Otieno, Walter, Bassat, Quique, Slutsker, L, Mordmüller, Benjamin, Slutsker, Laurence, Agyekum, Alex, Ofori-Anyinam, Opokua, Kaboré, W, Hamad, Ali Said, Doucka, Y, Wasuna, Ruth, Vansadia, Preeti, Otieno, A, Tahita, MC, Savarese, B, Lanaspa, Miguel, Ogutu, B, Gitaka, J, Lang, T, Drakeley, Chris, Issifou, S, Shomari, M, Abdul, O, Otieno, L, Otieno, K, Nyakuipa, D, Kaboré, William, Asante, Isaac, Gesase, Samwel, Cohen, Joe, Aide, P, Shubis, Kafuruki, Ogutu, Bernhards, Agnandji, Selidji Todagbe, Otieno, Lucas, Sambian, David, Kilavo, H, Adjei, S, Greenwood, B, Ansong, Daniel, Lell, Bertrand, Chandramohan, D, Awino, Norbert, Asante, KP, Rettig, T, Adjei, G, Gitaka, Jesse, Carter, Terrell, Juma, Omar, Gondi, S, Ouédraogo, JB, Tinto, H, Lemnge, M, Shomari, Mwanajaa, Guiguemdé, RT, Hoffman, Irving, Mvalo, T, Mtoro, Ali, Schellenberg, David, Quelhas, Diana, Radford, Afiya, Minja, Rose, Lievens, M, Cohen, J, Sorgho, H, Kerubo, Christine, Bawa, J, Theander, Thor, Ahmed, Saumu, Juma, O, Odero, Chris, Vekemans, Johan, Nkomo, Ruthendo, Muturi-Kioi, Vincent, Mvalo, Tisungane, RTS,S Clinical Trials Partnership, Theander, T, Tsofa, Benjamin, Dosoo, David, Ouédraogo, Jean Bosco, Mwangoka, Grace, Kremsner, PG, Jumbe, A, Otieno, W, Boateng, HO, Jongert, E, Rettig, Theresa, Conzelmann, C, Sorgho, Hermann, Flamen, A, Lell, B, Bejon, P, Ouédraogo, Sayouba, Osei-Kwakye, Kingsley, Agbenyega, Tsiri, Owira, Victorine, Nekoye, O, Issifou, Saadou, Muturi-Kioi, V, Ayamba, S, Kariuki, Simon, Methogo, BG, Oneko, Martina, Otieno, Kephas, Olotu, Ally, Lapierre, Didier, Fernandes, José Francisco, Macete, E, Owira, V, Ali, Ali Mohammed, Boahen, Owusu, Minja, R, Oneko, M, Onyango, Agnes Akoth, Leach, A, Liheluka, E, Sylverken, Justice, Lusingu, J, Hamel, Mary J, Salim, N, Vansadia, P, Owusu-Agyei, S, Njuguna, P, Kamthunzi, P, Macete, Eusébio, Mwangoka, G, Asante, Kwaku Poku, Owusu-Agyei, Seth, Fernandes, JF, Lemnge, Martha, Chintedza, J, Nhamuave, A, Ayamba, Samuel, Hamel, MJ, Msika, Albans, Kayan, Kingsley, Leboulleux, D, Alonso, Pedro, Kamthunzi, Portia, Marsh, K, Otieno, Allan, Kerubo, C, Ballou, W Ripley, Nekoye, Otsyula, Lanaspa, M, Shubis, K, Lievens, Marc, Sykes, A, Abossolo, Béatrice Peggy, Lapierre, D, Mandjate, Sofia, Chome, N, Ofori-Anyinam, O, Dosoo, D, Martinson, F, Marsh, Kevin, Urassa, Alwisa Martin, Mahende, Coline, Abdulla, S, Tsofa, B, Ali, AM, Boahen, O, Bassat, Q, Bawa, John, Sandrine, Yara, Osei-Kwakye, K, Peshu, N, Akoo, Pauline, Adjei, Samuel, Njuguna, Patricia, Jumbe, Allan, Williamson, John, Agbenyega, T, Sacarlal, J, Mtoro, A, Leboulleux, Didier, Greenwood, Brian, Malabeja, Anangisye, Wasuna, R, Chilengi, Roma, Schellenberg, D, Nhamuave, Arlindo, Guiguemdé, Robert Tinga, Awino, N, Tinto, Halidou, Tahita, Marc Christian, Mandjate, S, Asante, I, Martinson, Francis, Abossolo, BP, Tanner, M, Williamson, J, Kariuki, S, Machera, F, Kilavo, Hassan, Jones, D, Lusingu, John, Boateng, Harry Owusu, Chintedza, Joseph, Soulanoudjingar, Solange Solmeheim, Lang, Trudie, Sacarlal, Jahit, Gesase, S, Mahende, C, Ouédraogo, S, Bruls, Myriam, Guerra, Y, Msika, A, Soulanoudjingar, SS, Loucq, C, The RTS, S. Clinical Trials Partnership, Sykes, Alma, Agyekum, A, Owusu, L, Vekemans, J, Owusu, Larko, Odero, C, Tanner, Marcel, Laserson, Kayla F, Peshu, Norbert, Savarese, Barbara, Owusu-Ofori, Ruth, Omoto, J, Valea, Innocent, Chilengi, R, Bruls, M, D'Alessandro, Umberto, Onyango, AA, Hoffman, I, Salim, Nahya, Laserson, KF, D'Alessandro, U, Ballou, WR, Nkomo, R, Olotu, A   +282 more
core   +1 more source

Mapping the Social Network Structure and Composition of Black Individuals With Rheumatic and Musculoskeletal Conditions

Arthritis Care &Research, EarlyView.
Objective Our objective was to describe the social networks of Black individuals with rheumatic and musculoskeletal conditions and understand the clustering of health‐related behaviors to inform future community‐based, peer‐led interventions. Methods We used an adapted Personal Network Survey for Clinical Research (PERSNET) to map the personal social ...
Taussia Boadi, Amar Dhand, Leah Santacroce, Neil Pillai, Komel Safdar, Mia T. Chandler, Ariel Childs, Monica Crespo‐Bosque, Gina Curry, Mary Dollear, Alice Eggleston, Daniel Erickson, Dieufort Fleurissaint, Denice Garrett, Gail Granville, Tyler Green, Magdalena Hamielec, Elena Losina, Karen Mancera‐Cuevas, Mary Ann Nelson, Chisa Nosamiefan, Bisola Ojikutu, Tonya S. Roberson, Mary Beth Son, Marie Jacques Toussaint, Michael York, Rosalind Ramsey‐Goldman, Candace H. Feldman   +27 more
wiley   +1 more source

Enhancing enterovirus A71 vaccine production yield by microcarrier profusion bioreactor culture

, 2017
[[abstract]]Hand, foot and mouth diseases (HFMD) are mainly caused by Enterovirus A71 (EV-A71) infections. Clinical trials in Asia conducted with formalin-inactivated EV-A71 vaccine candidates produced from serum-free Vero cell culture using either ...
Liu, CC;Wu, SC;Wu, SR;Lin, HY;Guo, MS;Hu, AYC;Chow, YH;Chiang, JR;Shieh, DB;Chong, P
core   +1 more source

A review of the tolerability of the candidate TB vaccine, MVA85A compared with BCG and Yellow Fever vaccines, and correlation between MVA85A vaccine reactogenicity and cellular immunogenicity [PDF]

, 2012
© 2012 Elsevier Ltd. All rights reservedBackground: The development of a new, more effective vaccine against tuberculosis (TB) for use in healthy and HIV-infected adults, children and infants, remains a global health priority.
Minassian, Angela M, Porter, David W, Pathan, Ansar A, Rowland, Rosalind, Sander, C, Satti, Iman, Angela M Minassian, Nicola Williams, Lawrie, AM, Sander, Clare, Alison M Lawrie, Rowland, R, Poulton, ID, Rosalind Rowland, Brittain, N, Williams, Nicola, Pathan, AA, David W Porter, Minassian, AM, Helen McShane, Iman Satti, Ansar A Pathan, Ian D Poulton, Lawrie, Alison M, Nathaniel Brittain, Williams, N, Brittain, Nathaniel, Poulton, Ian D, Clare Sander, Porter, DW, Satti, I, McShane, H, McShane, Helen   +32 more
core   +1 more source

Myogenic Fusogen‐Engineered Lipid Nanoparticles Enhance mRNA Delivery in Skeletal Muscle

Advanced Functional Materials, EarlyView.
This study reports a biomimetic strategy of engineering full‐length Myomaker, a muscle‐specific fusogen, into lipid nanoparticles (LNPs) to harness the native myoblast fusion capability for skeletal muscle mRNA delivery. The resulting Mymk‐LNPs enhance transfection in differentiating myocytes and enable Cre‐mediated reporter activation in injured ...
Fangyu Zhang, Zhisheng Xu, Yaou Duan, Yehui Sun, Shiying Wu, Tao Long, Mateusz Durbacz, Li Zhang, Yufen Xiao, Yu‐Chung Pien, Erick D. Guerrero, Zeru Tian, Xu Wang, Pratima Basak, Sumanta Chatterjee, Ning Liu, Xiaochun Li, Eric N. Olson, Daniel J. Siegwart   +18 more
wiley   +1 more source

Production of EV71 vaccine candidates

, 2012
[[abstract]]Enterovirus 71 (EV71) is now recognized as an emerging neurotropic virus in Asia and with Coxsackie virus (CV) it is the other major causative agent of hand-foot-mouth diseases (HFMD).
Chong, P;Hsieh, SY;Liu, CC;Chou, AH;Yuan, CJ;Wu, SC;Liu, SJ;Chow, YH;Su, IJ;Klein, M
core   +1 more source

The Age of Cyclic Dinucleotide Vaccine Adjuvants

, 2020
As prophylactic vaccine adjuvants for infectious diseases, cyclic dinucleotides (CDNs) induce safe, potent, long-lasting humoral and cellular memory responses in the systemic and mucosal compartments.
Himanshu Gogoi, Lei Jin, Samira Mansouri
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Demonstration of safety and enhanced seroprotection against hepatitis B with investigational HBsAg-1018 ISS vaccine compared to a licensed hepatitis B vaccine

, 2012
Adults 40 years of age and older have been shown to be hypo-responsive immunologically to the currently available hepatitis B virus (HBV) vaccines. Three intramuscular doses of a Toll-like receptor 9 agonist, 1018 immunostimulatory sequence (1018 ISS ...
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