Results 81 to 90 of about 26,123,489 (353)

Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidence [PDF]

, 2012
Foremost amongst the diseases preventable by vaccination is influenza. Worldwide, influenza virus infection is associated with serious adverse events leading to hospitalization, debilitating complications, and death in elderly individuals ...
Assir N, Lang, Pierre-Olivier, Govind, Sheila, Aspinall R, Mendes A, Mendes, Aline, Socquet, Jennifer, Govind S, Socquet J, Assir, Noémie, Lang PO, Aspinall, Richard   +11 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design

eLife, 2017
Pathogens rely on proteins embedded on their surface to perform tasks essential for host infection. These obligatory structures exposed to the host immune system provide important targets for rational vaccine design.
Ching-Lin Hsieh, Christopher P Ptak, Andrew Tseng, Igor Massahiro de Souza Suguiura, Sean P McDonough, Tepyuda Sritrakul, Ting Li, Yi-Pin Lin, Richard E Gillilan, Robert E Oswald, Yung-Fu Chang   +10 more
doaj   +1 more source

Genomic Sequencing and Analysis of Eight Camel-Derived Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Isolates in Saudi Arabia

Viruses, 2020
Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans; the second-largest and most deadly outbreak to date occurred in Saudi Arabia.
Badr M. Al-Shomrani, Manee M. Manee, Sultan N. Alharbi, Mussad A. Altammami, Manal A. Alshehri, Majed S. Nassar, Muhammed A. Bakhrebah, Mohamed B. Al-Fageeh   +7 more
doaj   +1 more source

Immunoinformatic Analysis of T- and B-Cell Epitopes for SARS-CoV-2 Vaccine Design

Vaccines, 2020
Currently, there is limited knowledge about the immunological profiles of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). We used computer-based immunoinformatic analysis and the newly resolved 3-dimensional (3D) structures of the SARS-CoV ...
Dong-Liang Wang, Jinhui Mai, Wenfeng Zhou, Wanting Yu, Y. Zhan, Nai-Dong Wang, N. Epstein, Yi Yang   +7 more
semanticscholar   +1 more source

“The Impact of Mycobacterium tuberculosis Immune Evasion on Protective Immunity: Implications for TB Vaccine Design” – Meeting report [PDF]

, 2017
Tuberculosis (TB) is the major cause of death from infectious diseases around the world, particularly in HIV infected individuals. TB vaccine design and development have been focused on improving Bacille Calmette-Guérin (BCG) and evaluating recombinant ...
Ramachandra, Lakshmi, Porcelli, SA, Samuel Behar, Steven A. Porcelli, Hardy Kornfeld, Shea, Jaqueline, Ernst, JD, Boggiano, C, Cesar Boggiano, Eichelberg, Katrin, Ramakrishnan, Lalita, Maeurer, Markus, Kornfeld, Hardy, Ramachandra, L, Maeurer, M, Lalita Ramakrishnan, Ramakrishnan, L, Jaqueline Shea, Eichelberg, K, Markus Maeurer, Boggiano, Cesar, Behar, S, Kornfeld, H, Joel D. Ernst, Ernst, Joel D, Porcelli, Steven A, Lakshmi Ramachandra, Katrin Eichelberg, Behar, Samuel, Shea, J   +29 more
core   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Beyond Hot Spots: Biases in Antibody Somatic Hypermutation and Implications for Vaccine Design

Frontiers in Immunology, 2018
The evolution of antibodies in an individual during an immune response by somatic hypermutation (SHM) is essential for the ability of the immune system to recognize and remove the diverse spectrum of antigens that may be encountered.
Chaim A. Schramm, Daniel C. Douek
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Elicitation of liver-stage immunity by nanoparticle immunogens displaying P. falciparum CSP-derived antigens

npj Vaccines
A vaccine that provides robust, durable protection against malaria remains a global health priority. Although a breakthrough in the fight against malaria has recently been achieved by the licensure of two vaccines based on the circumsporozoite protein ...
Mark D. Langowski, Joseph R. Francica, Alex L. Roederer, Nicholas K. Hurlburt, Justas V. Rodarte, Lais Da Silva Pereira, Barbara J. Flynn, Brian Bonilla, Marlon Dillon, Patience Kiyuka, Rashmi Ravichandran, Connor Weidle, Lauren Carter, Mangala Rao, Gary R. Matyas, Marion Pepper, Azza H. Idris, Robert A. Seder, Marie Pancera, Neil P. King   +19 more
doaj   +1 more source