Results 91 to 100 of about 9,828,326 (308)

Evaluating the safety of influenza vaccine using a claims-based health system

, 2017
Introduction: As part of the Centers for Disease Control and Prevention's monitoring and evaluation activities for influenza vaccines, we examined relationships between influenza vaccination and selected outcomes in the 2009-2010 and 2010-2011 influenza ...
McCarthy, Natalie L.;Gee, Julianne;Lin, Nancy D.;Thyagarajan, Veena;Pan, Yi;Su, Sue;Turnbull, Bruce;Chan, K. Arnold;Weintraub, Eric, 陳建煒   +1 more
core   +1 more source

Evidence of blood stage efficacy with a virosomal malaria vaccine in a Phase IIa clinical trial [PDF]

, 2008
Background Previous research indicates that a combination vaccine targeting different stages of the malaria life cycle is likely to provide the most effective malaria vaccine.
Zurbriggen, R, Gerd Pluschke, Sarah C. Gilbert, Hill, Adrian, Hutchings, Claire, Gilbert Sarah C., Sinden, Robert, Gilbert, Sarah, Pluschke, G, Gilbert, Sarah C., Zurbriggen Rinaldo, Vogel, Denise, Jack L. Williams, Correa, S, Andrews Laura, Okitsu, SL, Westerfeld Nicole, Andrews, Laura, Vogel, D, David W. Porter, Thompson, Fiona, Okitsu, Shinji, Ian Poulton, Todryk, S, Shinji L. Okitsu, Denise Vogel, Dunachie Susanna, Thompson Fiona M., Berthoud, Tamara, Andrews, L, Sinden, R, Porter David W., Pluschke, Gerd, Sarah C Gilbert, Sinden Robert, Poulton Ian, Fiona M Thompson, Berthoud, T, Zurbriggen, Rinaldo, Rinaldo Zurbriggen, Susanna Dunachie, Westerfeld, Nicole, Tamara Berthoud, Todryk, Stephen, Okitsu Shinji L., Hill Adrian V. S., Correa Simon, Berthoud Tamara, Dunachie, S, Westerfeld, N, David W Porter, Nicole Westerfeld, Todryk Stephen, Porter, David, Correa, Simon, Thompson, FM, Pluschke Gerd, Hutchings, C, Poulton, Ian, Hutchings Claire, Williams, JL, Vogel Denise, Shinji L Okitsu, Fiona M. Thompson, Poulton, I, Jack L Williams, Simon Correa, Laura Andrews, Dunachie, Susanna, Adrian V S Hill, Robert Sinden, Porter, DW, Stephen Todryk, Williams, Jack, Claire Hutchings, Williams Jack L.   +75 more
core   +1 more source

From Cell‐Derived Vesicles to Hybrid Nanovectors: Biological Membranes as Functional Blueprints for Gene Delivery

Advanced Healthcare Materials, EarlyView.
Biologically derived and hybrid nonviral nanovectors are examined as distinct but convergent design approaches. Integrating synthetic components with biologically functionalized membranes allows efficient interactions with complex cellular environments.
Clara Baldari, Claudia Leone, Gabriella Leccese, Claudia De Stradis, Alessandra Invidia, Concetta Quintarelli, Biagio De Angelis, Franco Locatelli, Giuseppe Gigli, Gabriele Maiorano, Ilaria Elena Palamà   +10 more
wiley   +1 more source

Design of Nanoparticulate Group 2 Influenza Virus Hemagglutinin Stem Antigens That Activate Unmutated Ancestor B Cell Receptors of Broadly Neutralizing Antibody Lineages

mBio, 2019
Influenza vaccines targeting the highly conserved stem of the hemagglutinin (HA) surface glycoprotein have the potential to protect against pandemic and drifted seasonal influenza viruses not covered by current vaccines.
Kizzmekia S. Corbett, Syed M. Moin, Hadi M. Yassine, Alberto Cagigi, Masaru Kanekiyo, Seyhan Boyoglu-Barnum, Sky I. Myers, Yaroslav Tsybovsky, Adam K. Wheatley, Chaim A. Schramm, Rebecca A. Gillespie, Wei Shi, Lingshu Wang, Yi Zhang, Sarah F. Andrews, M. Gordon Joyce, Michelle C. Crank, Daniel C. Douek, Adrian B. McDermott, John R. Mascola, Barney S. Graham, Jeffrey C. Boyington   +21 more
doaj   +1 more source

Using simulation to estimate the power of a badger vaccine trial [PDF]

, 2011
The aim of this study was to estimate the power of a badger vaccine field trial using simulation techniques. The effects of sample size, sensitivity and specificity of the diagnostic test, transmission rate between unvaccinated badgers, Vaccine Efficacy ...
Aznar, I., More, S.J., Jong, M.C.M., de, Frankena, K.   +3 more
core  

Optimization of microcarrier cell culture process for the inactivated enterovirus type 71 vaccine development

, 2008
[[abstract]]Enterovirus 71 (EV71) is an enterovirus that could lead to severe neurological disorders and fatalities. The inactivated vaccine is an appropriate EV71 vaccine format for meeting current needs.
Wu, SC; Liu, CC; Lian, WC
core   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Leveraging ribosomal RNA as a molecular target for vaccine development against Acinetobacter baumannii

Future Journal of Pharmaceutical Sciences
Background Acinetobacter baumannii, a nosocomial pathogen, has emerged as a major clinical threat due to its ability to resist a broad range of antibiotics, contributing to the increased morbidity and mortality in hospital settings.
Elijah Kolawole Oladipo, Glory Jesudara Oluwasanya, Esther Oluwadarasimi Adaramola, Gbemisola Omolara Morawo, Blessing Jephthah Oluwalemu, Victor Oluwatobi Afolabi, Praise Akanni, Joel Damilare Ajagbe, Oluwadara Hannah Ojo, Fikayo Deborah Olayiwola, Shalom Busayo Akintola, Chris Olamide Balogun, Emmanuel Pelumi Kolapo, Ayomiposi Isaiah Oshoneye, Stephen Feranmi Adeyemo, Boluwatife Ayobami Irewolede, Bamidele Abiodun Iwalokun, Oluwatosin Akinola Ajibade, Olatunji Matthew Kolawole, Olubukola Monisola Oyawoye, Julius Kola Oloke, Helen Onyeaka   +21 more
doaj   +1 more source

Construction and evaluation of a Salmonella minicell-based dendritic cell-targeted multi-epitope vaccine against Helicobacter pylori

Frontiers in Immunology
BackgroundHelicobacter pylori (H. pylori) infection is a global health concern linked to various gastrointestinal diseases, highlighting the urgent need for effective vaccines.MethodsIn this study, we developed two multi-epitope vaccine candidates based ...
Jiaxue Yang, Kehan Chen, Yalan Zhu, Tiancheng Xie, Chubin Fang, Chuan Wang, Chuan Wang, Tian Tang, Tian Tang   +8 more
doaj   +1 more source