Results 111 to 120 of about 9,828,326 (308)

Intestinal Microbiota and Its Effect on Vaccine-Induced Immune Amplification and Tolerance

Vaccines
This review provides the potential of intestinal microbiota in vaccine design and application, exploring the current insights into the interplay between the intestinal microbiota and the immune system, with a focus on its intermediary function in vaccine
Yixin Liu, Jianfeng Zhou, Yushang Yang, Xiangzheng Chen, Longqi Chen, Yangping Wu   +5 more
doaj   +1 more source

A novel technology for the production of a heterologous lipoprotein immunogen in high yield has implications for the field of vaccine design

, 2009
[[abstract]]We have developed a novel platform technology that can express high levels of recombinant lipoproteins with intrinsic adjuvant properties. In this study, Ag473 (a lipoprotein from Neisseria meningitidis) can be produced in high yields using ...
Chen, HW;Liu, SJ;Liu, HH;Kwok, Y;Lin, CL;Lin, LH;Chen, MY;Tsai, JP;Chang, LS;Chiu, FF;Lai, Lw;Lian, WC;Yang, CY;Hsieh, SY;Chong, P;Leng, CH
core   +1 more source

Nanomaterials for Allergy Diagnosis and Treatment: Advances, Opportunities and Translational Challenges

Advanced Science, EarlyView.
Nanomaterials offer dual applications in allergy management. For diagnosis, nanomaterials enhance analytical sensitivity and improve detection in specific IgE and functional assays such as the basophil activation test (BAT). For allergen‐specific immunotherapy, nanomaterials enable allergen masking and controlled release, and effectively modulate the ...
Madiha Habib, Shan Jiang, Joyce ZX Lee, CW Lim, HL Yeung, Nicki YH Leung, Patrick SC Leung, Ting F Leung, Christine YY Wai   +8 more
wiley   +1 more source

An inclusive approach to designing a multi-epitope chimeric vaccine for Taenia infections by integrating proteomics and reverse vaccinology

Frontiers in Tropical Diseases
BackgroundSoil- and water-transmitted helminths are a major concern in the developing world due to their high prevalence. More than a quarter of the population were estimated to be infected with helminths in these endemic zones.Research designAn in ...
Swati Sharma, Ujjawal Sharan, Rimanpreet Kaur, Anubha Chaudhary, Suraj S. Rawat, Anand K. Keshri, Naina Arora, Amit Prasad, Amit Prasad, Amit Prasad   +9 more
doaj   +1 more source

Ultra‐Radiostable Covalent Conformationally Interlocked Networks Enabling a Universal Radiometal‐Labeling Platform for Cancer Radioembolization

Advanced Science, EarlyView.
Conjugated poly(imide dioxime)‐based microspheres establish a radiometal coordination‐driven conformational interlocked network with ultra‐high radiostability. This platform enables low‐temperature, multi‐radionuclide labeling for SPECT/PET/MRI imaging and radionuclide therapy. Mechanistic insights from EXAFS and DFT reveal enhanced stability, while in
Xiao Xu, Zhenwen Zhao, Yangjie Wang, Zhigang Liu, Zhijie Liu, Xiaoling Li, Zhichen Mao, Lu Xu, Gan Lin, Gang Liu, Hongjuan Ma   +10 more
wiley   +1 more source

Novel Inactivated Subtype B Avian Metapneumovirus Vaccine Induced Humoral and Cellular Immune Responses

, 2020
Avian metapneumovirus (aMPV), a highly contagious agent, is widespread and causes acute upper respiratory tract disease in chickens and turkeys. However, currently, there is no vaccine licensed in China.
Hongyu Cui, Peng Liu, Yuntong Chen, Zhuo Zhang, Xiaole Qi, Kai Li, Aijing Liu, Yuanling Bao, Farooque Muhammad, Xijun He, Zhihao Wang, Changjun Liu, Qing Pan, Yanping Zhang, Xinyi Li, Li Gao, Mengmeng Yu, Fujun Hou, Yulong Gao, Suyan Wang, Xiaomei Wang   +20 more
core   +1 more source

Optimizing rational vaccine design [PDF]

Microbial Biotechnology, 2009
Vaccines are the most cost‐efficient tool to prevent infectious diseases, and their therapeutic use, against both infectious and non‐infectious (e.g. cancer, autoimmunity) diseases, is gaining considerable interest. However, despite major advances in the fields of microbial pathogenesis, immunology and vaccinology, there are still many diseases for ...
openaire   +2 more sources

Porcine Deltacoronavirus M Protein Binds NLRP3 to Promote Inflammasome Assembly via Competition with TRIM31

Advanced Science, EarlyView.
Porcine deltacoronavirus (PDCoV) infection induces severe intestinal inflammation and acute diarrhea in piglets, yet the molecular mechanism remains incompletely understood. The M protein activates NLRP3 inflammasome through dual mechanisms: direct binding to the NLRP3 LRR domain and disruption of TRIM31‐mediated K48‐linked ubiquitination.
Jinhui Hou, Fangfang Han, Anqi Liu, Yang Yu, Rui Zhao, Zhengting Shi, Yanrong Lv, Jinli Liu, Shaopo Zu, Zhanyong Wei, Jin Yuan, Hui Hu   +11 more
wiley   +1 more source

Household survey of hepatitis B vaccine coverage among Brazilian children

, 2009
We conducted a multi-stage household cluster survey to calculate hepatitis B vaccine coverage among children 18-30 months of age in 27 Brazilian cities.
FLANNERY, Brendan, Vaccine Coverage Survey 2007 Grp, LUNA, Expedito J. A., MORAES, Jose Cassio de, VERAS, Maria Amelia S. M.   +4 more
core   +1 more source

A combinatorial approach to the design of vaccines

Journal of Mathematical Biology, 2014
We present two new problems of combinatorial optimization and discuss their applications to the computational design of vaccines. In the shortest λ-superstring problem, given a family S1,...,S(k) of strings over a finite alphabet, a set Τ of "target" strings over that alphabet, and an integer λ, the task is to find a string of minimum length containing,
Martínez, Luis, Milanič, Martin, Legarreta Solaguren, Leire, Medvedev, Paul, Malaina, Iker, Fuente, Ildefonso M. de la   +5 more
openaire   +2 more sources