Results 111 to 120 of about 26,123,489 (353)

An effective CTL peptide vaccine for Ebola Zaire Based on Survivors’ CD8+ targeting of a particular nucleocapsid protein epitope with potential implications for COVID-19 vaccine design

bioRxiv, 2020
The 2013-2016 West Africa EBOV epidemic was the biggest EBOV outbreak to date. An analysis of virus-specific CD8+ T-cell immunity in 30 survivors showed that 26 of those individuals had a CD8+ response to at least one EBOV protein. The dominant response (
C. Herst, Scott R. Burkholz, J. Sidney, A. Sette, Paul E. Harris, Shane Massey, T. Brasel, E. Cunha-Neto, D. S. Rosa, W. Chao, R. Carback, Tom Hodge, Lu Wang, Serban Ciotlos, P. Lloyd, Reid Rubsamen   +15 more
semanticscholar   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Phylogenetic and motif-based genomic analysis of Mokola virus: implications for regional divergence and data gaps

BMC Genomic Data
Mokola virus (MOKV), a member of the Lyssavirus genus, is an understudied zoonotic pathogen endemic to Africa, with sporadic detections in humans and animals.
Elijah Kolawole Oladipo, James Akinwumi Ogunniran, Oluwaseyi Samuel Akinpelu, Kehinde Abel Ajadi, Blessing Ogbene Andy, Hezekiah Oluwajoba Awobiyi, Bamidele Abiodun Iwalokun, Olatunji Matthew Kolawole, Helen Onyeaka, Julius Kola Oloke   +9 more
doaj   +1 more source

Translating Observations From Leishmanization Into Non-Living Vaccines: The Potential of Dendritic Cell-Based Vaccination Strategies Against Leishmania

Frontiers in Immunology, 2018
Leishmaniasis is a health-threatening vector-borne disease in almost 90 different countries. While a prophylactic human vaccine is not yet available, the fact that recovery from leishmaniasis establishes lifelong immunity against secondary infection ...
Negar Seyed, Nathan C. Peters, Sima Rafati   +2 more
doaj   +1 more source

Co-adjuvanting DDA/TDB liposomes with a TLR7 agonist allows for IgG2a/c class-switching in the absence of Th1 cells

npj Vaccines, 2023
Class-switching to IgG2a/c in mice is a hallmark response to intracellular pathogens. T cells can promote class-switching and the predominant pathway for induction of IgG2a/c antibody responses has been suggested to be via stimulation from Th1 cells.
Julie Zimmermann, Simon D. van Haren, Joann Diray-Arce, Ignatius Ryan Adriawan, Katharina Wørzner, Ricki T. Krog, Safia Guleed, Tu Hu, Rasmus Mortensen, Jes Dietrich, Sara M. Ø. Solbak, Ofer Levy, Dennis Christensen, Gabriel K. Pedersen   +13 more
doaj   +1 more source

BCG-Induced Cross-Protection and Development of Trained Immunity: Implication for Vaccine Design

Frontiers in Immunology, 2019
The Bacillus Calmette-Guérin (BCG) is a live attenuated tuberculosis vaccine that has the ability to induce non-specific cross-protection against pathogens that might be unrelated to the target disease.
Camila Covián, Ayleen Fernández-Fierro, A. Retamal-Díaz, F. E. Díaz, A. Vásquez, Margarita K. Lay, C. Riedel, P. González, S. Bueno, A. Kalergis   +9 more
semanticscholar   +1 more source

Phages in Vaccine Design and Immunity; Mechanisms and Mysteries

Current Opinion in Biotechnology, 2020
Bacteriophages have attracted extensive interest in vaccine design. This includes the use of phage display technology to select antigens, the use of engineered phages displaying target antigens in vaccine formulations, and phage DNA vaccines.
C. D. de Vries, Quingquan Chen, Sally Demirdjian, G. Kaber, A. Khosravi, Dan Liu, Jonas D. van Belleghem, P. Bollyky   +7 more
semanticscholar   +1 more source

Rationally designed tularemia vaccines [PDF]

Expert Review of Vaccines, 2009
Tularemia, caused by the Gram-negative bacterium Francisella tularensis, can be contracted by the bite of an arthropod vector or by inhalation. This disease occurs relatively infrequently but can be severe and even life-threatening if untreated. Until recently, there were few laboratories studying this organism; however, concerns over its potential use
Barbara J, Mann, Nicole M, Ark
openaire   +2 more sources

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Drug and Vaccine Design against Novel Coronavirus (2019-nCoV) Spike Protein through Computational Approach

, 2020
The recent outbreak of the new virus in Wuhan city, China from the sea food market has led to the identification of a new strain called the corona virus and named as novel corona virus (2019-nCoV) belonging to Coronaviridae family. This has created major
Suresh Kumar
semanticscholar   +1 more source