Results 131 to 140 of about 26,123,489 (353)

Leveraging ribosomal RNA as a molecular target for vaccine development against Acinetobacter baumannii

Future Journal of Pharmaceutical Sciences
Background Acinetobacter baumannii, a nosocomial pathogen, has emerged as a major clinical threat due to its ability to resist a broad range of antibiotics, contributing to the increased morbidity and mortality in hospital settings.
Elijah Kolawole Oladipo, Glory Jesudara Oluwasanya, Esther Oluwadarasimi Adaramola, Gbemisola Omolara Morawo, Blessing Jephthah Oluwalemu, Victor Oluwatobi Afolabi, Praise Akanni, Joel Damilare Ajagbe, Oluwadara Hannah Ojo, Fikayo Deborah Olayiwola, Shalom Busayo Akintola, Chris Olamide Balogun, Emmanuel Pelumi Kolapo, Ayomiposi Isaiah Oshoneye, Stephen Feranmi Adeyemo, Boluwatife Ayobami Irewolede, Bamidele Abiodun Iwalokun, Oluwatosin Akinola Ajibade, Olatunji Matthew Kolawole, Olubukola Monisola Oyawoye, Julius Kola Oloke, Helen Onyeaka   +21 more
doaj   +1 more source

HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design

Cell Host and Microbe, 2019
Summary Eliciting HIV-1-specific broadly neutralizing antibodies (bNAbs) remains a challenge for vaccine development, and the potential of passively delivered bNAbs for prophylaxis and therapeutics is being explored. We used neutralization data from four
Christine A. Bricault, K. Yusim, M. Seaman, H. Yoon, J. Theiler, E. Giorgi, K. Wagh, M. Theiler, P. Hraber, J. Macke, Edward F. Kreider, G. Learn, B. Hahn, J. Scheid, James M. Kovacs, Jennifer L. Shields, Christy L. Lavine, F. Ghantous, Michael J. Rist, Madeleine Bayne, George H. Neubauer, K. McMahan, Han-Qin Peng, C. Chéneau, Jennifer J. Jones, Jie Zeng, C. Ochsenbauer, Joseph P. Nkolola, K. Stephenson, Bing Chen, S. Gnanakaran, M. Bonsignori, L. D. Williams, B. Haynes, N. Doria-Rose, J. Mascola, D. Montefiori, D. Barouch, B. Korber   +38 more
semanticscholar   +1 more source

A systems framework for vaccine design

Current Opinion in Immunology, 2013
Numerous challenges have been identified in vaccine development, including variable efficacy as a function of population demographics and a lack of characterization and mechanistic understanding of immune correlates of protection able to guide delivery and dosing.
Mooney, Michael, McWeeney, Shannon, Canderan, Glenda, Sékaly, Rafick-Pierre   +3 more
openaire   +2 more sources

Immunological outcomes of new tuberculosis vaccine trials: WHO panel recommendations. [PDF]

, 2008
Willem Hanekom and colleagues make recommendations on assay harmonization for novel tuberculosis vaccine ...
Weichold Frank F, Willem A Hanekom, Uli J Fruth, T Mark Doherty, Hanekom Willem A, Doherty, T Mark, Hoft Dan F, Dan F Hoft, Shreemanta K Parida, Dockrell Hazel M, Helen Fletcher, Fruth Uli J, Hazel M Dockrell, McShane Helen, Weichold, Frank F, Frank F Weichold, Hoft, Dan F, Ottenhoff, Tom HM, Tom H M Ottenhoff, Helen McShane, Hanekom, Willem A, Fletcher Helen, Parida Shreemanta K, Fruth, Uli J, Doherty T. Mark, Parida, Shreemanta K, Dockrell, Hazel M, Fletcher, Helen, Ottenhoff Tom H. M, McShane, Helen   +29 more
core   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Construction and evaluation of a Salmonella minicell-based dendritic cell-targeted multi-epitope vaccine against Helicobacter pylori

Frontiers in Immunology
BackgroundHelicobacter pylori (H. pylori) infection is a global health concern linked to various gastrointestinal diseases, highlighting the urgent need for effective vaccines.MethodsIn this study, we developed two multi-epitope vaccine candidates based ...
Jiaxue Yang, Kehan Chen, Yalan Zhu, Tiancheng Xie, Chubin Fang, Chuan Wang, Chuan Wang, Tian Tang, Tian Tang   +8 more
doaj   +1 more source

Immunoinformatics Approach to Design a Multi-Epitope Vaccine against Cutaneous Leishmaniasis

, 2023
Cutaneous Leishmaniasis (CL), a neglected vector-borne disease caused by protozoan parasite Leishmania major (L. major), is a major public health concern, and the development of new strategies to reduce the disease incidence has become a top priority ...
Esra Atalay Şahar, Ayse Caner, Yusuf Ozbel, Shumaila Naz, Sumra Wajid Abbasi, Seray Toz, Aiman Aroosh, Naz, Shumaila, Ozbel, Yusuf, Toz, Seray, Caner, Ayse, Abbasi, Sumra Wajid, Aroosh, Aiman, Şahar, Esra Atalay   +13 more
core   +1 more source

Biomimetic Hybrid‐Membrane Nanoreactor for Deep‐Seated Photodynamic Immunotherapy of Hepatocellular Carcinoma via Dual Catalysis‐Enhanced ROS Amplification and cGAS‐STING Activation

Advanced Functional Materials, EarlyView.
UCNP@MnOx‐Hyp@HRM (UMHM) enables tumor targeting and accumulation. Under 808 nm NIR irradiation, PDT/CDT synergistically triggers ICD and cGAS–STING immunity for deep hepatocellular carcinoma therapy. ABSTRACT Photodynamic therapy (PDT) is promising against hepatocellular carcinoma (HCC).
Wen Li, Jianzhang Luo, Pei Lu, Dongqing Liu, Huijun Yi, Xiaoyuan Yi, Bixia Chi, Wen Chen, Qingyu Zeng, Feifei He, Liyan Wang   +10 more
wiley   +1 more source

Structural Vaccinology for Viral Vaccine Design

Frontiers in Microbiology, 2019
Although vaccines have proven pivotal against arrays of infectious viral diseases, there are still no effective vaccines against many viruses. New structural insights into the viral envelope, protein conformation, and antigenic epitopes can guide the ...
M. Anasir, C. Poh
semanticscholar   +1 more source

Vaccine effectiveness estimates, 2004-2005 mumps outbreak, England. [PDF]

, 2007
The United Kingdom and United States have recently experienced large outbreaks of mumps, which raises concerns about vaccine effectiveness. The effectiveness of the mumps component of the measles, mumps, rubella (MMR) vaccine was estimated using the ...
Savage, Emma J, Cheryl Cohen, Judith R. Glynn, Andrews, Nick, Ramsay, Mary E, Cohen, Cheryl, Brown, David, Joanne M. White, Glynn, Judith R, Emma J. Savage, Choi, Yoon, David Brown, White, Joanne M, Yoon Choi, Mary E. Ramsay, Nick Andrews   +15 more
core   +1 more source