Results 61 to 70 of about 3,636,379 (304)

Designing a multi-epitope influenza vaccine: an immunoinformatics approach

Scientific Reports
Influenza continues to be one of the top public health problems since it creates annual epidemics and can start a worldwide pandemic. The virus's rapid evolution allows the virus to evade the host defense, and then seasonal vaccines need to be reformulated nearly annually.
Leila Momajadi, Hossein Khanahmad, Karim Mahnam   +2 more
openaire   +3 more sources

A New Epitope Selection Method: Application to Design a Multi-Valent Epitope Vaccine Targeting HRAS Oncogene in Squamous Cell Carcinoma

, 2021
We developed an epitope selection method for the design of MHC targeting peptide vaccines. The method utilizes predictions for several clinical checkpoint filters, including binding affinity, immunogenicity, antigenicity, half-life, toxicity, IFNγ ...
Kush Savsani, Gabriel Jabbour, Sivanesan Dakshanamurthy   +2 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Design a multi-epitope vaccine candidate against Acinetobacter baumannii using advanced computational methods

AMB Express
Acinetobacter baumannii is a significant cause of hospital-acquired infections and is often resistant to multiple antibiotics. In this study, we designed a multi-epitope vaccine candidate using the outer membrane protein K (OmpK) of A. baumannii.
Hana Heidarinia, Elahe Tajbakhsh, Yadollah Bahrami, Mosayeb Rostamian   +3 more
doaj   +1 more source

Vaccine Design for H5N1 Based on B- and T-cell Epitope Predictions

, 2016
From 2003 to 2013, Indonesia had the highest number of avian influenza A cases in humans, with 192 cases and 160 fatalities. Avian influenza is caused by influenza virus type A, such as subtype H5N1.
Usman Sumo Friend Tambunan, Feimmy Ruth Pratiwi Sipahutar, Arli Aditya Parikesit, Djati Kerami   +3 more
core   +1 more source

Mitochondria‐Targeted Nanotherapies in Aging Neurodegenerative Disorders: Emerging Prospects and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Mitochondria‐targeted nanotherapies emerge as a promising strategy for combating aging‐associated neurodegenerative disorders (NDs) by restoring mitochondrial function, reducing oxidative stress, and improving neuronal survival. Recent advances in nanotechnology, therapeutic delivery, and translational research are highlighted, providing insights into ...
Dnyandev G. Gadhave, Ashish B. Jadhav, Nitin B. Waghamode, Shubham Khot, Rajiya Khan, Ravi Hole, Shankar M. Dhobale, Manoj Aswar, Keshav Raj Paudel   +8 more
wiley   +1 more source

Enhancement of Tetravalent Immune Responses to Highly Conserved Epitopes of a Dengue Peptide Vaccine Conjugated to Polystyrene Nanoparticles

Vaccines, 2020
Vaccination remains the major approach to the prevention of dengue. Since the only licensed live attenuated vaccine (LAV) lacked efficacy against all four serotypes, other vaccine platforms, such as synthetic peptide vaccines, should be explored. In this
Yanqi Chan, Seyed Davoud Jazayeri, Babu Ramanathan, Chit Laa Poh   +3 more
doaj   +1 more source

A randomised, double-blind, controlled vaccine efficacy trial of DNA/MVA ME-TRAP against malaria infection in Gambian adults. [PDF]

, 2004
BACKGROUND: Many malaria vaccines are currently in development, although very few have been evaluated for efficacy in the field. Plasmodium falciparum multiple epitope (ME)- thrombospondin-related adhesion protein (TRAP) candidate vaccines are designed ...
Greenwood, Brian M, Pauline Kaye, Hill Adrian S. V, Kaye, Pauline, Imoukhuede, Egeruan B, Gilbert, Sarah, Walraven, G, Vasee S Moorthy, Moorthy Vasee S, Hill, AS, Egeruan B Imoukhuede, Kalifa Bojang, Milligan Paul, Gilbert, Sarah C, Pinder Margaret, Walraven, Gijs, Margaret Pinder (1712), Gijs Walraven, Adrian S V Hill, Hill, Adrian SV, Imoukhuede, EB, Egeruan B Imoukhuede (57141), Brian M Greenwood (45474), Walraven Gijs, Bojang, Kalifa, Brian M Greenwood, Keating, S, Vasee S Moorthy (57140), Greenwood Brian M, Sarah C Gilbert, Gilbert, SC, Kalifa Bojang (57143), Greenwood, BM, Bojang, K, Paul Milligan (57142), Pauline Kaye (57145), Gijs Walraven (18413), Moorthy, Vasee S, Kaye, P, Gilbert Sarah C, Pinder, M, Keating, Sheila, Sarah C Gilbert (57146), Paul Milligan, Sheila Keating (57144), Milligan, Paul, Moorthy, VS, Adrian S. V Hill (57147), Bojang Kalifa, Kaye Pauline, Sheila Keating, Milligan, P, Margaret Pinder, Keating Sheila, Pinder, Margaret, Imoukhuede Egeruan B   +55 more
core   +2 more sources

How is Nanoarchitectonics Shaping Extracellular Vesicle Research?

Advanced Healthcare Materials, EarlyView.
The convergence of nanoarchitectonics and extracellular vesicle biology is reshaping next‐generation nanomedicine by enabling rationally designed nanostructures for enhanced EVs detection, engineering, and therapy. ABSTRACT Extracellular vesicles (EVs) have gained recognition as crucial mediators of cell‐to‐cell communication, holding immense potential
Madushani Dahanayake, Md Shahriar A. Hossain, Chia‐Hung Liu, Carlos Salomon, Yusuke Yamauchi, Mostafa Kamal Masud   +5 more
wiley   +1 more source

Synthetic B-Cell Epitopes Eliciting Cross-Neutralizing Antibodies: Strategies for Future Dengue Vaccine.

PLoS ONE, 2016
Dengue virus (DENV) is a major public health threat worldwide. A key element in protection from dengue fever is the neutralising antibody response. Anti-dengue IgG purified from DENV-2 infected human sera showed reactivity against several peptides when ...
Babu Ramanathan, Chit Laa Poh, Kristin Kirk, William John Hannan McBride, John Aaskov, Lara Grollo   +5 more
doaj   +1 more source