Results 51 to 60 of about 50,861 (164)

Bioinformatics Design of a DBV-Specific Multi-Epitope Vaccine [PDF]

BIO Web of Conferences
Objective This study aims to design and optimize a multi-epitope vaccine against Dabie bandavirus (DBV) using bioinformatics approaches, and to systematically evaluate its structural stability, antigenicity, and immunogenicity, thereby providing a ...
Zhu Yuheng, Liu Jingxian, Xiao Zhongdang
doaj   +1 more source

Immunoinformatics-Based Design of Multi-epitope DNA and mRNA Vaccines Against Zika Virus

Bioinformatics and Biology Insights
In this study, we used an immunoinformatics approach to predict antigenic epitopes of Zika virus (ZIKV) proteins to assist in designing a vaccine antigen against ZIKV. We performed the prediction of CD8+ T-lymphocyte and antigenic B-cell epitopes of ZIKV
Juciene de Matos Braz, Marcus Vinicius de Aragão Batista   +1 more
doaj   +1 more source

Computational Design of a VLP-based Multi-Epitope Peptide Vaccine Candidate against Breast Cancer [PDF]

Journal of Ardabil University of Medical Sciences
Background: Breast cancer is a leading cause of cancer-related mortality in women, and finding effective treatments is essential. Among different cancer immunotherapy strategies, vaccines play a prominent role.
Nasim Hajighahramani, Fatemeh Ghasempour
doaj  

Design of multi-epitope-based therapeutic vaccine candidates from HBc and HBx proteins of hepatitis B virus using reverse vaccinology and immunoinformatics approaches.

PLoS ONE
The major problem in cases of chronic hepatitis B (CHB) is the failure of the patient's immune response to eliminate the covalently closed circular DNA (cccDNA) minichromosome of hepatitis B virus (HBV).
Patricia Gita Naully, Marselina Irasonia Tan, Husna Nugrahapraja, Aluicia Anita Artarini, Reza Aditama, Ernawati Arifin Giri-Rachman   +5 more
doaj   +1 more source

A bioinformatics pipeline for the design of a SART3-targeted cancer vaccine with enhanced immunogenicity

Genomics & Informatics
Background and objectives Squamous cell carcinoma antigen recognized by T-cells 3 (SART3) has emerged as a promising target for cancer immunotherapy, given its overexpression in various malignancies and low or absent expression in non-tumorous tissues ...
Zeynab Bayat, Faezeh Mahdian-Khoo, Lida Samie, Amir Taherkhani   +3 more
doaj   +1 more source

Clinical Serum-Anchored Computational Design Pipeline for a Broad-Spectrum Influenza Multi-Epitope mRNA Vaccine

Biology
Influenza’s pandemic threat is driven by antigenic drift, which limits the efficacy of conventional vaccines. To address this challenge, we established a clinical serum-anchored computational design pipeline for a broad-spectrum multi-epitope mRNA ...
Lifang Yuan, Zhiyao Ouyang, Yifan Zhao, Rongjun Bi, Yanjing Wu, Xu Li, Yingrui Li, Jiaping Song, Wei Li, Mingchen Yan, Simin Wen, Huanle Luo, Tian Bai, Yuelong Shu, Yongkun Chen   +14 more
doaj   +1 more source

A therapeutic multi-epitope protein vaccine targeting HPV16 E6 E7 elicits potent tumor regression and cytotoxic immune responses

Cancer Biology & Medicine
Objective: Cervical cancer caused by persistent high-risk human papillomavirus (hrHPV) infection remains a leading cause of cancer-related mortality in women.
Lanfang Zhu, Jingtao Pu, Yufen Tao, Lei Shi, Shuyuan Liu, Xinwen Zhang, Weipeng Liu, Ming Sun, Yufeng Yao, Li Shi   +9 more
doaj   +1 more source

Bioinformatics-Based Prediction of Potential Immunogenic Epitopes in E. tenella ROP Proteins as Candidate Vaccine Targets [PDF]

Journal of Advanced Biomedical Sciences
Background & Objective: Avian coccidiosis, caused by protozoan parasites of the genus Eimeria, imposes substantial economic losses on the global poultry industry. Rhoptry proteins (ROPs), as critical virulence determinants involved in host cell invasion,
Nastaran Paknejad, Ali Dalir Ghaffari, Mahdi Khadem Mohammadi   +2 more
doaj  

HLA-A2-Restricted Epitopes Identified from MTA1 Could Elicit Antigen-Specific Cytotoxic T Lymphocyte Response

Journal of Immunology Research, 2018
Overexpression of metastasis-associated protein 1 (MTA1) has been observed in many human malignancies and is significantly related to tumor invasion and metastasis, therapeutic resistance to radiation and chemotherapy, making MTA1 an ideal candidate ...
Yahong Wu, Wenjie Zhai, Xiuman Zhou, Zhiwei Wang, Yan Lin, Ling Ran, Yuanming Qi, Yanfeng Gao   +7 more
doaj   +1 more source

Identification of an antigenic epitope for helper T lymphocytes from carcinoembryonic antigen.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2002
The product of the carcinoembryonic antigen (CEA) gene is an attractive candidate for T-cell-based immunotherapy because it is frequently expressed in epithelial solid carcinomas. Although many CEA peptide epitopes capable of stimulating CTLs have been identified, no MHC class II-restricted T helper epitope has yet been reported.The amino acid sequence
Borras-Cuesta, F. (Francisco), Herraiz-Bayod, M.J. (Maite J.), Kobayashi, H. (Hiroya), Ruiz, M. (Marta), Sangro, B. (Bruno), Omiya, R. (Ryusuke), Prieto, J. (Jesús), Huarte, E. (Eduardo), Sarobe, P. (Pablo), Celis, E. (Esteban), Lasarte, J.J. (Juan José)   +10 more
openaire   +2 more sources