Results 31 to 40 of about 2,776 (178)

In-silico Design of Multi-epitope Vaccine against Nipah Virus using Immunoinformatics Approach

, 2021
Nipah virus is a pleomorphic virus that causes high mortality with unpredictable outbreaks. The virus also shows high zoonotic potential with long term neurological damage after recovery further adding to the disease burden.
Suraj Raju, Debasish Sahoo, Vikas Kumar Bhari   +2 more
core   +1 more source

Immunoinformatics: A Basic Bibliometric Analysis [PDF]

ImmunoAnalysis, 2021
Background: Traditionally, immunologists have been using experimental methods for a long time, which have generated functional, clinical and epidemiological data. So, it is inevitable to develop and apply novel computational approaches to collect, store, analyze, and report the latent knowledge behind these data.
Elaheh Rahimpour, Taha Samad-Soltani
openaire   +2 more sources

Association of pyroptosis and severeness of COVID-19 as revealed by integrated single-cell transcriptome data analysis

ImmunoInformatics, 2022
Cytokine storm and inflammatory cytokine release syndrome are often found to be associated with severe instances of the 2019 coronavirus disease (COVID-19). However, factors that contribute to the development of the COVID-19-associated cytokine storm and
Qian Xu, Yongjian Yang, Xiuren Zhang, James J. Cai   +3 more
doaj   +1 more source

Epitope identification of SARS-CoV-2 structural proteins using in silico approaches to obtain a conserved rational immunogenic peptide

ImmunoInformatics, 2022
The short time between the first cases of COVID-19 and the declaration of a pandemic initiated the search for ways to stop the spread of SARS-CoV-2. There are great expectations regarding the development of effective vaccines that protect against all ...
Leonardo Pereira de Araújo, Maria Eduarda Carvalho Dias, Gislaine Cristina Scodeler, Ana de Souza Santos, Letícia Martins Soares, Patrícia Paiva Corsetti, Ana Carolina Barbosa Padovan, Nelson José de Freitas Silveira, Leonardo Augusto de Almeida   +8 more
doaj   +1 more source

Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response

ImmunoInformatics, 2021
Response to cancer immunotherapies depends on the complex and dynamic interactions between T cell recognition and killing of cancer cells that are counteracted through immunosuppressive pathways in the tumor microenvironment.
Shuming Zhang, Chang Gong, Alvaro Ruiz-Martinez, Hanwen Wang, Emily Davis-Marcisak, Atul Deshpande, Aleksander S. Popel, Elana J. Fertig   +7 more
doaj   +1 more source

Systematic review of reverse vaccinology and immunoinformatics data for non-viral sexually transmitted infections [PDF]

, 2023
Sexually Transmitted Infections (STIs) are a public health burden rising in developed and developing nations. The World Health Organization estimates nearly 374 million new cases of curable STIs yearly.
ARISTÓTELES GOÉS NETO, FLÁVIA F. ABURJAILE, SIOMAR C. SOARES, VASCO AZEVEDO, MARIANA V. DIAS, ARUN K. JAISWAL, DIEGO LUCAS N. RODRIGUES, JOYCE C.F. DUTRA, GLEN J.Y. GARCÍA, RODRIGO PROFETA, SANDEEP TIWARI, LUCAS GABRIEL R. GOMES   +11 more
core   +2 more sources

Immune checkpoint therapy modeling of PD-1/PD-L1 blockades reveals subtle difference in their response dynamics and potential synergy in combination

ImmunoInformatics, 2021
Immune checkpoint therapy is one of the most promising immunotherapeutic methods that are likely able to give rise to durable treatment response for various cancer types.
Kamran Kaveh, Feng Fu
doaj   +1 more source

Image_3_Designing a multi-epitope vaccine against coxsackievirus B based on immunoinformatics approaches.png

, 2022
Coxsackievirus B (CVB) is one of the major viral pathogens of human myocarditis and cardiomyopathy without any effective preventive measures; therefore, it is necessary to develop a safe and efficacious vaccine against CVB.
Fengzhen Deng (14079264), Xinnan Hu (14079267), Yushu Deng (14079270), Wenran Zhao (6989219), Yanhang Wang (14079273), Congcong Zhang (334270), Zongmao Dai (14079261), Sichao Huang (4031558), Zhaohua Zhong (213963), Yuxuan Li (1674307), Jingjing Huang (170112), Yan Wang (15435), Xumeng Wang (12238019), Xinxin Yue (8628432), Jianing Li (359834)   +14 more
core   +1 more source

Table_1_Designing a multi-epitope vaccine against coxsackievirus B based on immunoinformatics approaches.docx

, 2022
Coxsackievirus B (CVB) is one of the major viral pathogens of human myocarditis and cardiomyopathy without any effective preventive measures; therefore, it is necessary to develop a safe and efficacious vaccine against CVB.
Fengzhen Deng (14079264), Xinnan Hu (14079267), Yushu Deng (14079270), Wenran Zhao (6989219), Yanhang Wang (14079273), Congcong Zhang (334270), Zongmao Dai (14079261), Sichao Huang (4031558), Zhaohua Zhong (213963), Yuxuan Li (1674307), Jingjing Huang (170112), Yan Wang (15435), Xumeng Wang (12238019), Xinxin Yue (8628432), Jianing Li (359834)   +14 more
core   +1 more source

SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein

ImmunoInformatics, 2022
The Omicron (BA.1/B.1.1.529) variant of SARS-CoV-2 harbors an alarming 37 mutations on its spike protein, reducing the efficacy of current COVID-19 vaccines. In this study, we identified CD8+ and CD4+ T cell epitopes from SARS-CoV-2 S protein mutants. To
Simone Parn, Kush Savsani, Sivanesan Dakshanamurthy   +2 more
doaj   +1 more source