Results 31 to 40 of about 7,150 (221)

XML in Motion from Genome to Drug [PDF]

, 2007
Information technology (IT) has emerged as a central to the solution of contemporary genomics and drug discovery problems. Researchers involved in genomics, proteomics, transcriptional profiling, high throughput structure determination, and in other sub ...
C. Gopi Mohan
core   +2 more sources

Simulating the decentralized processes of the human immune system in a virtual anatomy model [PDF]

, 2013
BACKGROUND: Many physiological processes within the human body can be perceived and modeled as large systems of interacting particles or swarming agents.
Christian Jacob, Vladimir Sarpe
core   +2 more sources

Immunoinformatics and tick vaccinology

Exploration of Immunology, 2023
Immunoinformatics is an emerging area focused on development and applications of methods used to facilitate vaccine development. There is a growing interest in the field of vaccinology centered on the new omic science named ‘vaccinomics’. However, this approach has not succeeded to provide a solution against major infections affecting both animals and ...
Rodrigo Rosario-Cruz, Delia Inés Domínguez-García, Saúl López-Silva, Fernando Rosario-Domínguez   +3 more
openaire   +1 more source

Manganese mediates antiviral effects by driving an ATM -TBK1 phosphorylation signaling pathway

Frontiers in Immunology
Ataxia-telangiectasia mutated (ATM) is traditionally recognized as a nuclear kinase involved in DNA damage repair. We were the first to report that ATM also participates in a manganese (Mn)-dependent TBK1 phosphorylation pathway.
Hongyan Sui, Rosana Wiscovitch-Russo, Silvia Cachaco, Silvia Cachaco, Jun Yang, Whitney Bruchey, Sylvain Laverdure, Qian Chen, Tomozumi Imamichi   +8 more
doaj   +1 more source

Immunoinformatics Comes of Age

PLoS Computational Biology, 2006
With the burgeoning immunological data in the scientific literature, scientists must increasingly rely on Internet resources to inform and enhance their work. Here we provide a brief overview of the adaptive immune response and summaries of immunoinformatics resources, emphasizing those with Web interfaces.
Bette Korber, Montiago LaBute, Karina Yusim   +2 more
openaire   +4 more sources

Tools and data services registry: a community effort to document bioinformatics resources. [PDF]

, 2015
Life sciences are yielding huge data sets that underpin scientific discoveries fundamental to improvement in human health, agriculture and the environment.
Anthon, C., Beard, N., Berka, K., Bolser, D., Booth, T., Bretaudeau, A., Brezovsky, J., Brunak, S., Casadio, R., Cesareni, G., Chmura, P., Coppens, F., Cornell, M., Cuccuru, G., Davidsen, K., de la Torre, V., Dogan, T., Doppelt-Azeroual, O., Emery, L., Friborg, R.M., Gasteiger, E., Gatter, T., Goldberg, T., Grosjean, M., Grüning, B., Helmer-Citterich, M., Ienasescu, H., Ioannidis, V., Ison, J., Jespersen, M.C., Jimenez, R., Juty, N., Juvan, P., Kalaš, M., Koch, M., Laibe, C., Li, J.W., Licata, L., Løngreen, P., Mareuil, F., Mičetić, I., Moretti, S., Morris, C., Ménager, H., Möller, S., Nenadic, A., Parkinson, H., Peterson, H., Profiti, G., Rapacki, K., Rice, P., Romano, P., Roncaglia, P., Rost, B., Rydza, E., Saidi, R., Schafferhans, A., Schwämmle, V., Smith, C., Sperotto, M.M., Stockinger, H., Tosatto, S.C., Uva, P., Vařeková, R.S., Vedova, G.D., Via, A., Vriend, G., Yachdav, G., Zambelli, F.   +68 more
core   +15 more sources

AntigenDB: an immunoinformatics database of pathogen antigens [PDF]

Nucleic Acids Research, 2009
The continuing threat of infectious disease and future pandemics, coupled to the continuous increase of drug-resistant pathogens, makes the discovery of new and better vaccines imperative. For effective vaccine development, antigen discovery and validation is a prerequisite.
Ansari, Hifzur R., Flower, Darren R, Raghava, G.P.S.   +2 more
openaire   +3 more sources

Immunoinformatic Analysis of Human Thyroglobulin [PDF]

Cybernetics and Information Technologies, 2020
Abstract The AutoImmune ThyroiDitis (AITD), known as Hashimoto’s disease, is a chronic autoimmune thyroid disease progressively developed to hypothyroidism. The AITD is characterized by the formation of autoantibodies targeting two specific thyroid antigens, Thyroglobulin (Tg) and Thyroid PerOxidase (TPO).
Doytchinova Irini, Tchorbanov Andrey, Ivanov Stefan   +2 more
openaire   +2 more sources

Interleukin-27-polarized HIV-resistant M2 macrophages are a novel subtype of macrophages that express distinct antiviral gene profiles in individual cells: implication for the antiviral effect via different mechanisms in the individual cell-dependent manner

Frontiers in Immunology
IntroductionInterleukin (IL)-27 is an anti-viral cytokine. IL-27-treated monocyte-derived macrophages (27-Mac) suppressed HIV replication. Macrophages are generally divided into two subtypes, M1 and M2 macrophages.
Tomozumi Imamichi, Jun Yang, Qian Chen, Suranjana Goswami, Mayra Marquez, Udeshika Kariyawasam, Homa Nath Sharma, Rosana Wiscovitch-Russo, Xuan Li, Akihiro Aioi, Joseph W. Adelsberger, Weizhong Chang, Jeanette Higgins, Hongyan Sui   +13 more
doaj   +1 more source

The CHARME "Advanced Big Data Training School for Life Sciences": an example of good practices for training on current bioinformatics challenges [PDF]

, 2019
The CHARME “Advanced Big Data Training School for Life Sciences” took place during 3-7 September 2018, at the Campus Nord of the Technical University of Catalonia (UPC) in Barcelona (ES).
Duarte López, Ariel, Hoang, Yen, Papageorgiou, K., Pfeil, Juliane, Pérez Casany, Marta, Ramšak, Živa, Schulze, Sabrina K., Zagoršcak, Maja, Zdravevski, Eftim   +8 more
core   +2 more sources