Results 11 to 20 of about 4,043 (182)

Immunoinformatics-Based Multi-Epitope Vaccine Targeting Helicobacter Pylori. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background The rising global incidence of Helicobacter pylori‐related diseases, particularly gastric cancer, underscores the urgent need for effective preventive vaccines, motivating the exploration of innovative immunoinformatic strategies to address this public health challenge.
Pasha AVK, Esfandiyari M, Parnian A, Mahboubi-Rabbani M, Bayanati M.   +4 more
europepmc   +2 more sources

Is Toxoplasma gondii-secreted Protein With an Altered Thrombospondin Repeat (TgSPATR) a Potential Candidate for Immunisation? An Immunoinformatics-Based Analysis. [PDF]

Vet Med Sci
Toxoplasma gondii‐secreted protein with an altered thrombospondin repeat was computationally characterised as an immunogenic, non‐allergenic protein carrying multiple B‐ and T‐cell epitopes. Structural validation and immune simulation suggest its strong potential as a vaccine candidate against toxoplasmosis.
Foroutan M, Karimzadeh-Soureshjani E, Ghaffarifar F.   +2 more
europepmc   +2 more sources

ImmunoNodes – graphical development of complex immunoinformatics workflows [PDF]

BMC Bioinformatics, 2017
Background Immunoinformatics has become a crucial part in biomedical research. Yet many immunoinformatics tools have command line interfaces only and can be difficult to install.
Benjamin Schubert, Luis de la Garza, Christopher Mohr, Mathias Walzer, Oliver Kohlbacher   +4 more
doaj   +6 more sources

Correction: Manganese mediates antiviral effects by driving an ATM-TBK1 phosphorylation signaling pathway [PDF]

Frontiers in Immunology
Hongyan Sui, Rosana Wiscovitch-Russo, Silvia Cachaco, Silvia Cachaco, Jun Yang, Whitney Bruchey, Sylvain Laverdure, Qian Chen, Tomozumi Imamichi   +8 more
doaj   +2 more sources

The C-Terminal Domain of RNase H and the C-Terminus Amino Acid Residue Regulate Virus Release and Autoprocessing of a Defective HIV-1 Possessing M50I and V151I Changes in Integrase

Viruses, 2022
Previously, we reported that an HIV-1 variant containing Met-to-Ile change at codon 50 and Val-to-Ile mutation at codon 151 of integrase (IN), HIV(IN:M50I/V151I), was an impaired virus.
Tomozumi Imamichi, Qian Chen, Ming Hao, Weizhong Chang, Jun Yang   +4 more
doaj   +1 more source

Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

iScience, 2022
Summary: Trace metals are essential for various physiological processes, but their roles in innate immunity have not been fully explored. Here, we found that manganese (Mn) significantly enhanced DNA-mediated IFN-α, IFN-β, and IFN-λ1 production ...
Hongyan Sui, Qian Chen, Jun Yang, Selena Srirattanapirom, Tomozumi Imamichi   +4 more
doaj   +1 more source

A Combination of M50I and V151I Polymorphic Mutations in HIV-1 Subtype B Integrase Results in Defects in Autoprocessing

Viruses, 2021
We have recently reported that a recombinant HIV-1NL4.3 containing Met-to-Ile change at codon 50 of integrase (IN) (IN:M50I) exhibits suppression of the virus release below 0.5% of WT HIV, and the released viral particles are replication-incompetent due ...
Jun Yang, Ming Hao, Muhammad A. Khan, Muhammad T. Rehman, Helene C. Highbarger, Qian Chen, Suranjana Goswami, Brad T. Sherman, Catherine A. Rehm, Robin L. Dewar, Weizhong Chang, Tomozumi Imamichi   +11 more
doaj   +1 more source

Interleukin-27 promotes autophagy in human serum-induced primary macrophages via an mTOR- and LC3-independent pathway

Scientific Reports, 2021
Interleukin-27 (IL-27) is a cytokine that suppresses human immunodeficiency virus (HIV)-1 infection in macrophages and is considered as an immunotherapeutic reagent for infectious diseases.
Sylvain Laverdure, Ziqiu Wang, Jun Yang, Takuya Yamamoto, Tima Thomas, Toyotaka Sato, Kunio Nagashima, Tomozumi Imamichi   +7 more
doaj   +1 more source

INDI – Integrated Nanobody Database for Immunoinformatics [PDF]

Nucleic Acids Research, 2021
Abstract Nanobodies, a subclass of antibodies found in camelids, are a versatile molecular binding scaffold composed of a single polypeptide chain. The small size of nanobodies bestows multiple therapeutic advantages (stability, tumor penetration) with the first therapeutic approval in 2018 cementing the clinical ...
Piotr Deszynski, Jakub Mlokosiewicz, Adam Volanakis, Igor Jaszczyszyn, Natalie Castellana, Stefano Bonissone, Rajkumar Ganesan, Konrad Krawczyk   +7 more
openaire   +3 more sources

Molecular identification, characterization, and antagonistic activity profiling of Bacillus cereus LOCK 1002 along with the in-silico analysis of its presumptive bacteriocins

Journal of Advanced Veterinary and Animal Research, 2022
Objectives: This research aimed to isolate, identify, and characterize a new strain of Bacillus cereus through different molecular biology approaches so that it could be further studied for therapeutic purposes against selective enteric pathogens ...
Samarth Islam, Mithila Farjana, Muhammad Ramiz Uddin, Sharmin Akter, Anika Jabin, Hazika Tuz-Zohura Nafisa, Siam Siraji, A K M Helal Morshed, Fahmida Hoque Rimti, Zannatul Naim, Mohiuddin Sakib, Pallab Sarker, Sabiha Naznin, H.M. Iftekhar Alam, Tanzila Ismail Ema, Mahbuba Siddiquy, Mohammad Habibur Rahman   +16 more
doaj   +1 more source