Results 11 to 20 of about 2,776 (178)

FRED 2: an immunoinformatics framework for Python [PDF]

Bioinformatics, 2016
Immunoinformatics approaches are widely used in a variety of applications from basic immunological to applied biomedical research. Complex data integration is inevitable in immunological research and usually requires comprehensive pipelines including ...
Kohlbacher, O., Walzer, M., Brachvogel, H., Szolek, A., Schubert, B., Mohr , C.   +5 more
core   +5 more sources

ImmunoNodes – graphical development of complex immunoinformatics workflows

BMC Bioinformatics, 2017
Background Immunoinformatics has become a crucial part in biomedical research. Yet many immunoinformatics tools have command line interfaces only and can be difficult to install.
Benjamin Schubert, Luis de la Garza, Christopher Mohr, Mathias Walzer, Oliver Kohlbacher   +4 more
doaj   +2 more sources

Immunoinformatics comes of age.

PLoS Computational Biology, 2006
With the burgeoning immunological data in the scientific literature, scientists must increasingly rely on Internet resources to inform and enhance their work.
Bette Korber, Karina Yusim, Montiago LaBute   +2 more
core   +5 more sources

Immunoinformatics: Predicting Peptide–MHC Binding [PDF]

Annual Review of Biomedical Data Science, 2020
Immunoinformatics is a discipline that applies methods of computer science to study and model the immune system. A fundamental question addressed by immunoinformatics is how to understand the rules of antigen presentation by MHC molecules to T cells, a ...
Andreatta, Massimo, Peters, Bjoern, Søren Buus, Buus, Søren, Morten Nielsen, Bjoern Peters, Nielsen, Morten, Massimo Andreatta   +7 more
core   +6 more sources

Immunoglobulins: 25 Years of Immunoinformatics and IMGT-ONTOLOGY [PDF]

Biomolecules, 2014
IMGT®, the international ImMunoGeneTics information system® (CNRS and Montpellier University) is the global reference in immunogenetics and immunoinformatics.
Marie-Paule Lefranc
core   +4 more sources

The C-Terminal Domain of RNase H and the C-Terminus Amino Acid Residue Regulate Virus Release and Autoprocessing of a Defective HIV-1 Possessing M50I and V151I Changes in Integrase

Viruses, 2022
Previously, we reported that an HIV-1 variant containing Met-to-Ile change at codon 50 and Val-to-Ile mutation at codon 151 of integrase (IN), HIV(IN:M50I/V151I), was an impaired virus.
Tomozumi Imamichi, Qian Chen, Ming Hao, Weizhong Chang, Jun Yang   +4 more
doaj   +1 more source

Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

iScience, 2022
Summary: Trace metals are essential for various physiological processes, but their roles in innate immunity have not been fully explored. Here, we found that manganese (Mn) significantly enhanced DNA-mediated IFN-α, IFN-β, and IFN-λ1 production ...
Hongyan Sui, Qian Chen, Jun Yang, Selena Srirattanapirom, Tomozumi Imamichi   +4 more
doaj   +1 more source

Riding the wave of innovation: immunoinformatics in fish disease control [PDF]

, 2023
The spread of infectious illnesses has been a significant factor restricting aquaculture production. To maximise aquatic animal health, vaccination tactics are very successful and cost-efficient for protecting fish and aquaculture animals against many ...
Siti Aisyah Razali, Wan-Atirah Azemin, Nur Farahin Ishak, Mohd Shahir Shamsir, Chen-Fei Low   +4 more
core   +2 more sources

A Combination of M50I and V151I Polymorphic Mutations in HIV-1 Subtype B Integrase Results in Defects in Autoprocessing

Viruses, 2021
We have recently reported that a recombinant HIV-1NL4.3 containing Met-to-Ile change at codon 50 of integrase (IN) (IN:M50I) exhibits suppression of the virus release below 0.5% of WT HIV, and the released viral particles are replication-incompetent due ...
Jun Yang, Ming Hao, Muhammad A. Khan, Muhammad T. Rehman, Helene C. Highbarger, Qian Chen, Suranjana Goswami, Brad T. Sherman, Catherine A. Rehm, Robin L. Dewar, Weizhong Chang, Tomozumi Imamichi   +11 more
doaj   +1 more source

INDI – Integrated Nanobody Database for Immunoinformatics [PDF]

Nucleic Acids Research, 2021
Abstract Nanobodies, a subclass of antibodies found in camelids, are a versatile molecular binding scaffold composed of a single polypeptide chain. The small size of nanobodies bestows multiple therapeutic advantages (stability, tumor penetration) with the first therapeutic approval in 2018 cementing the clinical ...
Piotr Deszynski, Jakub Mlokosiewicz, Adam Volanakis, Igor Jaszczyszyn, Natalie Castellana, Stefano Bonissone, Rajkumar Ganesan, Konrad Krawczyk   +7 more
openaire   +4 more sources