Results 11 to 20 of about 7,150 (221)

ImmunoNodes – graphical development of complex immunoinformatics workflows [PDF]

BMC Bioinformatics, 2017
Background Immunoinformatics has become a crucial part in biomedical research. Yet many immunoinformatics tools have command line interfaces only and can be difficult to install.
Benjamin Schubert, Luis de la Garza, Christopher Mohr, Mathias Walzer, Oliver Kohlbacher   +4 more
doaj   +5 more sources

Immunoinformatics-Based Multi-Epitope Vaccine Targeting Helicobacter Pylori. [PDF]

Cancer Rep (Hoboken)
ABSTRACT Background The rising global incidence of Helicobacter pylori‐related diseases, particularly gastric cancer, underscores the urgent need for effective preventive vaccines, motivating the exploration of innovative immunoinformatic strategies to address this public health challenge.
Pasha AVK, Esfandiyari M, Parnian A, Mahboubi-Rabbani M, Bayanati M.   +4 more
europepmc   +2 more sources

INDI – Integrated Nanobody Database for Immunoinformatics [PDF]

Nucleic Acids Research, 2021
AbstractNanobodies, a subclass of antibodies found in camelids, are a versatile molecular binding scaffold composed of a single polypeptide chain. The small size of nanobodies bestows multiple therapeutic advantages (stability, tumor penetration) with the first therapeutic approval in 2018 cementing the clinical viability of this format.
Piotr Deszyński, Jakub Młokosiewicz, Adam Volanakis, Igor Jaszczyszyn, Natalie Castellana, Stefano Bonissone, Rajkumar Ganesan, Konrad Krawczyk   +7 more
openaire   +3 more sources

Is Toxoplasma gondii-secreted Protein With an Altered Thrombospondin Repeat (TgSPATR) a Potential Candidate for Immunisation? An Immunoinformatics-Based Analysis. [PDF]

Vet Med Sci
Toxoplasma gondii‐secreted protein with an altered thrombospondin repeat was computationally characterised as an immunogenic, non‐allergenic protein carrying multiple B‐ and T‐cell epitopes. Structural validation and immune simulation suggest its strong potential as a vaccine candidate against toxoplasmosis.
Foroutan M, Karimzadeh-Soureshjani E, Ghaffarifar F.   +2 more
europepmc   +2 more sources

Immunoinformatics: Predicting Peptide–MHC Binding [PDF]

Annual Review of Biomedical Data Science, 2020
Immunoinformatics is a discipline that applies methods of computer science to study and model the immune system. A fundamental question addressed by immunoinformatics is how to understand the rules of antigen presentation by MHC molecules to T cells, a process that is central to adaptive immune responses to infections and cancer.
Nielsen, Morten, Andreatta, Massimo, Peters, Bjoern, Buus, Søren   +3 more
openaire   +4 more sources

Immunoinformatics: an integrated scenario [PDF]

Immunology, 2010
SummaryGenome sequencing of humans and other organisms has led to the accumulation of huge amounts of data, which include immunologically relevant data. A large volume of clinical data has been deposited in several immunological databases and as a result immunoinformatics has emerged as an important field which acts as an intersection between ...
Namrata, Tomar, Rajat K, De
openaire   +2 more sources

Review of Immunoinformatic approaches to in-silico B-cell epitope prediction [PDF]

, 2007
In this paper, the current state of in-silico, B-cell epitope prediction is discussed. Recommendations for improving some of the approaches encountered are outlined, along with the presentation of an entirely novel technique, which uses molecular ...
Rick Reitmaier
core   +2 more sources

Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response

ImmunoInformatics, 2021
Response to cancer immunotherapies depends on the complex and dynamic interactions between T cell recognition and killing of cancer cells that are counteracted through immunosuppressive pathways in the tumor microenvironment.
Shuming Zhang, Chang Gong, Alvaro Ruiz-Martinez, Hanwen Wang, Emily Davis-Marcisak, Atul Deshpande, Aleksander S. Popel, Elana J. Fertig   +7 more
doaj   +1 more source

Computer aided selection of candidate vaccine antigens [PDF]

, 2010
Immunoinformatics is an emergent branch of informatics science that long ago pullulated from the tree of knowledge that is bioinformatics. It is a discipline which applies informatic techniques to problems of the immune system.
Darren R Flower, Irini A Doytchinova, Isabel K Macdonald, Kamna Ramakrishnan, Matthew N Davies   +4 more
core   +2 more sources

A pull-down assay using DNA/RNA-conjugated beads with a customized competition strategy: An effective approach to identify DNA/RNA binding proteins

MethodsX, 2020
Innate immune response is insisted upon detection of foreign intracellular DNA or RNA derived from viruses and bacteria. This reaction is important to initiate an effective protective response for the host cells. This crucial step is induced by cytosolic
Hongyan Sui, Qian Chen, Tomozumi Imamichi   +2 more
doaj   +1 more source