Results 21 to 30 of about 4,043 (182)

Immunoinformatics: an integrated scenario [PDF]

Immunology, 2010
SummaryGenome sequencing of humans and other organisms has led to the accumulation of huge amounts of data, which include immunologically relevant data. A large volume of clinical data has been deposited in several immunological databases and as a result immunoinformatics has emerged as an important field which acts as an intersection between ...
Namrata, Tomar, Rajat K, De
openaire   +2 more sources

Point-specific interactions of isovitexin with the neighboring amino acid residues of the hACE2 receptor as a targeted therapeutic agent in suppressing the SARS-CoV-2 influx mechanism

Journal of Advanced Veterinary and Animal Research, 2022
Objective: Despite the development of several vaccines against severe acute respiratory syndrome coronavirus-2, the need for an additional prophylactic agent is evident.
Nourin Ferdausi, Samarth Islam, Fahmida Hoque Rimti, Syeda Tasnim Quayum, Efat Muhammad Arshad, Aashian Ibnat, Tamnia Islam, Adittya Arefin, Tanzila Ismail Ema, Partha Biswas, Dipta Dey, Salauddin Al Azad   +11 more
doaj   +1 more source

Association of pyroptosis and severeness of COVID-19 as revealed by integrated single-cell transcriptome data analysis

ImmunoInformatics, 2022
Cytokine storm and inflammatory cytokine release syndrome are often found to be associated with severe instances of the 2019 coronavirus disease (COVID-19). However, factors that contribute to the development of the COVID-19-associated cytokine storm and
Qian Xu, Yongjian Yang, Xiuren Zhang, James J. Cai   +3 more
doaj   +1 more source

Immunopeptidomic Data Integration to Artificial Neural Networks Enhances Protein-Drug Immunogenicity Prediction

Frontiers in Immunology, 2020
Recombinant DNA technology has, in the last decades, contributed to a vast expansion of the use of protein drugs as pharmaceutical agents. However, such biological drugs can lead to the formation of anti-drug antibodies (ADAs) that may result in adverse ...
Carolina Barra, Chloe Ackaert, Birkir Reynisson, Jana Schockaert, Leon Eyrich Jessen, Mark Watson, Anne Jang, Simon Comtois-Marotte, Jean-Philippe Goulet, Sofie Pattijn, Eustache Paramithiotis, Morten Nielsen, Morten Nielsen   +12 more
doaj   +1 more source

Epitope identification of SARS-CoV-2 structural proteins using in silico approaches to obtain a conserved rational immunogenic peptide

ImmunoInformatics, 2022
The short time between the first cases of COVID-19 and the declaration of a pandemic initiated the search for ways to stop the spread of SARS-CoV-2. There are great expectations regarding the development of effective vaccines that protect against all ...
Leonardo Pereira de Araújo, Maria Eduarda Carvalho Dias, Gislaine Cristina Scodeler, Ana de Souza Santos, Letícia Martins Soares, Patrícia Paiva Corsetti, Ana Carolina Barbosa Padovan, Nelson José de Freitas Silveira, Leonardo Augusto de Almeida   +8 more
doaj   +1 more source

Integrating single cell sequencing with a spatial quantitative systems pharmacology model spQSP for personalized prediction of triple-negative breast cancer immunotherapy response

ImmunoInformatics, 2021
Response to cancer immunotherapies depends on the complex and dynamic interactions between T cell recognition and killing of cancer cells that are counteracted through immunosuppressive pathways in the tumor microenvironment.
Shuming Zhang, Chang Gong, Alvaro Ruiz-Martinez, Hanwen Wang, Emily Davis-Marcisak, Atul Deshpande, Aleksander S. Popel, Elana J. Fertig   +7 more
doaj   +1 more source

A pull-down assay using DNA/RNA-conjugated beads with a customized competition strategy: An effective approach to identify DNA/RNA binding proteins

MethodsX, 2020
Innate immune response is insisted upon detection of foreign intracellular DNA or RNA derived from viruses and bacteria. This reaction is important to initiate an effective protective response for the host cells. This crucial step is induced by cytosolic
Hongyan Sui, Qian Chen, Tomozumi Imamichi   +2 more
doaj   +1 more source

Immune checkpoint therapy modeling of PD-1/PD-L1 blockades reveals subtle difference in their response dynamics and potential synergy in combination

ImmunoInformatics, 2021
Immune checkpoint therapy is one of the most promising immunotherapeutic methods that are likely able to give rise to durable treatment response for various cancer types.
Kamran Kaveh, Feng Fu
doaj   +1 more source

Immunoinformatics Comes of Age

PLoS Computational Biology, 2006
With the burgeoning immunological data in the scientific literature, scientists must increasingly rely on Internet resources to inform and enhance their work. Here we provide a brief overview of the adaptive immune response and summaries of immunoinformatics resources, emphasizing those with Web interfaces.
Bette T. Korber, Montiago LaBute, Karina Yusim   +2 more
openaire   +4 more sources

SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein

ImmunoInformatics, 2022
The Omicron (BA.1/B.1.1.529) variant of SARS-CoV-2 harbors an alarming 37 mutations on its spike protein, reducing the efficacy of current COVID-19 vaccines. In this study, we identified CD8+ and CD4+ T cell epitopes from SARS-CoV-2 S protein mutants. To
Simone Parn, Kush Savsani, Sivanesan Dakshanamurthy   +2 more
doaj   +1 more source