Results 21 to 30 of about 7,150 (221)

Immune checkpoint therapy modeling of PD-1/PD-L1 blockades reveals subtle difference in their response dynamics and potential synergy in combination

ImmunoInformatics, 2021
Immune checkpoint therapy is one of the most promising immunotherapeutic methods that are likely able to give rise to durable treatment response for various cancer types.
Kamran Kaveh, Feng Fu
doaj   +1 more source

SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein

ImmunoInformatics, 2022
The Omicron (BA.1/B.1.1.529) variant of SARS-CoV-2 harbors an alarming 37 mutations on its spike protein, reducing the efficacy of current COVID-19 vaccines. In this study, we identified CD8+ and CD4+ T cell epitopes from SARS-CoV-2 S protein mutants. To
Simone Parn, Kush Savsani, Sivanesan Dakshanamurthy   +2 more
doaj   +1 more source

Modeling interaction of Glioma cells and CAR T-cells considering multiple CAR T-cells bindings

ImmunoInformatics, 2023
Chimeric antigen receptor (CAR) T-cell based immunotherapy has shown its potential in treating blood cancers, and its application to solid tumors is currently being extensively investigated.
Runpeng Li, Prativa Sahoo, Dongrui Wang, Qixuan Wang, Christine E. Brown, Russell C. Rockne, Heyrim Cho   +6 more
doaj   +1 more source

Controlling influenza by cytotoxic T-cells : calling for help from destroyers [PDF]

, 2010
Influenza is a vaccine preventable disease that causes severe illness and excess mortality in humans. Licensed influenza vaccines induce humoral immunity and protect against strains that antigenically match the major antigenic components of the vaccine ...
Schotsaert, Michael, Ibanez, Lorena, Fiers, Walter, Saelens, Xavier   +3 more
core   +2 more sources

pDOCK: a new technique for rapid and accurate docking of peptide ligands to Major Histocompatibility Complexes [PDF]

, 2010
10.1186/1745-7580-6-S1-S2Immunome Research6SUPPL ...
Javed Khan, Shoba Ranganathan
core   +1 more source

The antibody loci of the domestic goat (Capra hircus) [PDF]

, 2018
The domestic goat (Capra hircus) is an important ruminant species both as a source of antibody-based reagents for research and biomedical applications and as an economically important animal for agriculture, particularly for developing nations that ...
Bickhart, Derek M., Hammond, John A., Philp, Rebecca L., Schwartz, John C., Smith, Timothy P.L.   +4 more
core   +1 more source

Immunization with Hypoallergens of Shrimp Allergen Tropomyosin Inhibits Shrimp Tropomyosin Specific IgE Reactivity [PDF]

, 2014
published_or_final_versio
Chu, KH, Gershwin, LJ, Ho, MHK, Leung, NYH, Leung, PSC, Shu, SA, Wai, CYY   +6 more
core   +1 more source

Immunoinformatics: A Basic Bibliometric Analysis [PDF]

ImmunoAnalysis, 2021
Background: Traditionally, immunologists have been using experimental methods for a long time, which have generated functional, clinical and epidemiological data. So, it is inevitable to develop and apply novel computational approaches to collect, store, analyze, and report the latent knowledge behind these data.
Elaheh Rahimpour, Taha Samad-Soltani
openaire   +2 more sources

Recent advances in T-cell receptor repertoire analysis: Bridging the gap with multimodal single-cell RNA sequencing

ImmunoInformatics, 2022
T cells exercise a multitude of functions such as cytotoxicity, secretion of immunomodulating cytokines or regulation of tolerance, collectively resulting in an effective control of immune-related disease.
Sebastiaan Valkiers, Nicky de Vrij, Sofie Gielis, Sara Verbandt, Benson Ogunjimi, Kris Laukens, Pieter Meysman   +6 more
doaj   +1 more source

The race to understand immunopathology in COVID-19: Perspectives on the impact of quantitative approaches to understand within-host interactions

ImmunoInformatics, 2023
The COVID-19 pandemic has revealed the need for the increased integration of modelling and data analysis to public health, experimental, and clinical studies.
Sonia Gazeau, Xiaoyan Deng, Hsu Kiang Ooi, Fatima Mostefai, Julie Hussin, Jane Heffernan, Adrianne L. Jenner, Morgan Craig   +7 more
doaj   +1 more source