Results 41 to 50 of about 101,363 (247)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Communication Signal Modulation Recognition Method Based on Multi-Feature Multi-Channel ResNet and BiLSTM Neural Network

Sensors
To deal with the insufficient recognition accuracy of traditional signal modulation recognition methods, this paper proposes a new communication signal modulation recognition method with a deep neural network that integrates a multi-feature multi-channel
Xi Li, Xuan Geng, Yanli Xu, Fang Cao
doaj   +1 more source

MSLF-Net: A Multi-Scale and Multi-Level Feature Fusion Net for Diabetic Retinopathy Segmentation

Diagnostics, 2022
Diabetic Retinopathy (DR) is a diabetic complication that predisposes patients to visual impairments that could lead to blindness. Lesion segmentation using deep learning algorithms is an effective measure to screen and prevent early DR.
Haitao Yan, Jiexin Xie, Deliang Zhu, Lukuan Jia, Shijie Guo   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Scene Text Detection Based on Multi-scale Feature Extraction and Bidirectional Feature Fusion

Journal of Harbin University of Science and Technology
Natural scene text detection is a fundamental research work in the field of image processing and has a wide range of applications. Currently, natural scene text detection usually adopts single-scale convolution and multi-scale feature fusion to ...
LIAN Zhe, YIN Yanjun, ZHI Min, XU Qiaozhi   +3 more
doaj   +1 more source

Regularization Meets Enhanced Multi-Stage Fusion Features: Making CNN More Robust against White-Box Adversarial Attacks

Sensors, 2022
Regularization has become an important method in adversarial defense. However, the existing regularization-based defense methods do not discuss which features in convolutional neural networks (CNN) are more suitable for regularization.
Jiahuan Zhang, Keisuke Maeda, Takahiro Ogawa, Miki Haseyama   +3 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Underwater Acoustic Target Feature Fusion Method Based on Multi-Kernel Sparsity Preserve Multi-Set Canonical Correlation Analysis

Xibei Gongye Daxue Xuebao, 2019
To solve high-dimensional and small-sample-size classification problem for underwater target recognition, a new feature fusion method is proposed based on multi-kernel sparsity preserve multi-set canonical correlation analysis.

doaj   +1 more source