Results 91 to 100 of about 765,097 (272)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Multi-frequency VLBA observations of compact sources from the Peacock & Wall catalogue

, 2005
VLBA observations are presented for 6 compact radio sources selected from the Peacock & Wall catalogue. From the new morphological and spectral information 2 objects that in the Peacock and Wall catalogue are flat spectrum (alpha < 0.5) sources, appear ...
A. Rossetti, Akujor, Baum, Becker, Bogers, Bondi, C. Fanti, Carvalho, Comastri, Cotton, D. Dallacasa, Dallacasa, Dallacasa, F. Mantovani, Fanti, Fanti, Fanti, Fanti, Fanti, Fey, Fey, Fomalont, Fugmann, Giroletti, Herbig, Hummel, Hummel, Impey, Johnston, Junor, Kellermann, Kühr, Laing, Lister, Lüdke, Marcaide, Murgia, Murgia, Nan, O'Dea, O'Dea, Owsianik, Patnaik, Peacock, Peacock, Pearson, Perlman, Phillips, Piner, Polatidis, Polatidis, Pyatunina, R. Fanti, Readhead, Readhead, Sanghera, Shaffer, Snellen, Snellen, Spencer, Stanghellini, Stanghellini, Stanghellini, Stickel, Taylor, Taylor, Taylor, Tschager, von Montigny, Wiik, Wilkinson, Wilkinson, Xu   +72 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Learning Multi-Frequency Partial Correlation Graphs

IEEE Transactions on Signal Processing
Despite the large research effort devoted to learning dependencies between time series, the state of the art still faces a major limitation: existing methods learn partial correlations but fail to discriminate across distinct frequency bands. Motivated by many applications in which this differentiation is pivotal, we overcome this limitation by ...
Gabriele D’Acunto, Paolo Di Lorenzo, Francesco Bonchi, Stefania Sardellitti, Sergio Barbarossa   +4 more
openaire   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Optimal Carrier-Phase Integer Combinations for Modernized Triple-Frequency BDS in Precise Point Positioning

IEEE Access, 2019
The latest generation of Global Navigation Satellite System (GNSS) satellites are transmitting signals on three or more frequencies, it brings new opportunities and challenges for data integration in Multi-GNSS Experiment (MGEX).
Honglei Qin, Peng Liu, Jiaqing Qu, Li Cong   +3 more
doaj   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Multi-Frequency Noise Reduction Method for Underwater Radiated Noise of Autonomous Underwater Vehicles

Journal of Marine Science and Engineering
The multi-frequency noisy vibration of an autonomous underwater vehicle (AUV) is a significant factor affecting the performance of shear probes mounted on the head of AUVs.
Beibei Mao, Hua Yang, Wenbo Li, Xiaoyu Zhu, Yuxuan Zheng   +4 more
doaj   +1 more source