Results 101 to 110 of about 784,718 (264)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

MFF-Net: Flood Detection from SAR Images Using Multi-Frequency and Fuzzy Uncertainty Fusion

Remote Sensing
Synthetic Aperture Radar (SAR) images are highly valuable for detecting water surfaces characterized by low roughness and minimal microwave reflection, which makes them essential for flood detection.
Yahui Gao, Xiaochuan Wang, Zili Zhang, Xiaoming Chen, Ruijun Liu, Xiaohui Liang   +5 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Two-Stage Multi-Frequency Deep Learning for Electromagnetic Imaging of Uniaxial Objects

Mathematics
In this paper, an anisotropic object electromagnetic image reconstruction system based on a two-stage multi-frequency extended network is developed by deep learning techniques.
Wei-Tsong Lee, Chien-Ching Chiu, Po-Hsiang Chen, Guan-Jang Li, Hao Jiang   +4 more
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Effects of Equatorial Plasma Bubbles on Multi-GNSS Signals: A Case Study over South China

Remote Sensing
Equatorial plasma bubbles (EPBs) occur frequently in low-latitude areas and have a non-negligible impact on navigation satellite signals. To systematically analyze the effects of a single EPB event on multi-frequency signals of GPS, Galileo, GLONASS, and
Hao Han, Jiahao Zhong, Yongqiang Hao, Ningbo Wang, Xin Wan, Fuqing Huang, Qiaoling Li, Xingyan Song, Jiawen Chen, Kang Wang, Yanyan Tang, Zhuoliang Ou, Wenyu Du   +12 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Assessment of Sea-Ice Classification Capabilities during Melting Period Using Airborne Multi-Frequency PolSAR Data

Remote Sensing
Sea-ice mapping using Synthetic Aperture Radar (SAR) in the melt season poses challenges, primarily due to meltwater complicating the distinguishability of sea-ice types. In response to this issue, this study introduces a novel method for classifying sea
Peng Wang, Xi Zhang, Lijian Shi, Meijie Liu, Genwang Liu, Chenghui Cao, Ruifu Wang   +6 more
doaj   +1 more source