Results 91 to 100 of about 4,285,302 (266)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Load–frequency control : a GA-based multi-agent reinforcement learning
, 2010 The load–frequency control (LFC) problem has been one of the major subjects in a power system. In\ud practice, LFC systems use proportional–integral (PI) controllers.
Bevrani, Hassan, Daneshfar, Fatheme
core +1 more source
Multi-Omic Factors Associated with Frequency of Upper Respiratory Infections in Developing Infants
, 2023 Susceptibility to upper respiratory infections (URIs) may be influenced by host, microbial, and environmental factors. We hypothesized that multi-omic analyses of molecular factors in infant saliva would identify complex host-environment interactions ...
Ramin Beheshti (14659709) +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
IEEE Access, 2019 The latest generation of Global Navigation Satellite System (GNSS) satellites are transmitting signals on three or more frequencies, it brings new opportunities and challenges for data integration in Multi-GNSS Experiment (MGEX).
Honglei Qin +3 more
doaj +1 more source
Multi-frequency telecom fibered laser system for potassium laser cooling
, 2021 We describe a compact and versatile multi-frequency laser system for laser-cooling potassium atoms, by frequency doubling a fiber-optic telecom beam ($\simeq 1534$ or $1540$~nm).
Samir Zemmouri (14407098) +9 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Journal of Marine Science and EngineeringThe multi-frequency noisy vibration of an autonomous underwater vehicle (AUV) is a significant factor affecting the performance of shear probes mounted on the head of AUVs.
Beibei Mao +4 more
doaj +1 more source
5G network intelligent scheduling based on core network analysis and decision
Dianxin kexue, 2021 Larger bandwidth and complex technology of the 5G networks inevitably bring a significant increase in overall energy consumption, so green energy-saving of mobile networks has attracted widespread attention.The long-term coexistence of 5G and 4G, as well
Qingyang WANG +3 more
doaj