Results 161 to 170 of about 1,432 (217)

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

ML Workflows for Screening Degradation‐Relevant Properties of Forever Chemicals

Advanced Science, EarlyView.
The environmental persistence of per‐ and polyfluoroalkyl substances (PFAS) necessitates efficient remediation strategies. This study presents physics‐informed machine learning workflows that accurately predict critical degradation properties, including bond dissociation energies and polarizability.
Pranoy Ray, Andrew R. Castillo, Manoj Kolel‐Veetil, Surya R. Kalidindi   +3 more
wiley   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

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Validity of laryngomalacia classification systems: A multi‐institutional agreement study

Clinical Otolaryngology, 2020
AbstractObjectivesTo determine the agreement of paediatric otolaryngologists on classifying laryngomalacia (LM).DesignIntra‐ and interobserver agreement study of two classification systems.SettingThree tertiary referral paediatric centres.ParticipantsThree paediatric otolaryngologists, who were blinded to any clinical details, interpreted the videos of
Shanmugappiriya Sivarajah, Andre Isaac, Shelaina Anderson, Deepak Mehta, Paul Hong, Yaser Alrajhi, Hamdy El‐Hakim   +6 more
openaire   +2 more sources

The variability of clinical thermoluminescent dosimetry systems: A multi‐institutional study

Medical Physics, 1987
Thirty‐two radiotherapy centers in the USA and Canada cooperated in a study of the variability of clinical thermoluminescent dosimetry (TLD) systems. The primary purpose of the survey was to ascertain the accuracy of TLD for the determination of in vivo dose measurements.
H I, Amols, M S, Weinhous, L E, Reinstein   +2 more
openaire   +2 more sources

Failure factors in multi-institutional systems formation

Health Care Management Review, 1983
While some attempts at multihospital systems formation do not succeed, there are many things that can be learned from their failure to be applicable to new organizational efforts.
openaire   +2 more sources

Realizing a Secure Federation of Multi-institutional Service Systems

2005
Today, many organizations and individuals are creating a large variety of services. However, even if these services are connected through a network, there are very few examples where such services operate in an interconnected way. One reason for this is the lack of systems that are able to coordinate multiple systems, with different schemes for user ...
Yu Enokibori, Nobuhiko Nishio
openaire   +1 more source

Multi-Institutional Service System Developments for High Risk Infants

Journal of Health & Social Policy, 1991
This article describes the development of a county-wide multi-institutional follow-up system for a high risk population of children and their families and proposes guidelines for health service system building. The target population for this program known as the Alliance for Infants and based in Allegheny County, Pennsylvania, was the very low ...
C L, Young, C J, Groark, G J, Wasson
openaire   +2 more sources

Multi-institutional validation of a web-based core competency assessment system

Journal of Surgical Education, 2007
The Association of Program Directors in Surgery and the Division of Education of the American College of Surgeons developed and implemented a web-based system for end-of-rotation faculty assessment of ACGME core competencies of residents. This study assesses its reliability and validity across multiple programs.Each assessment included ratings (1-5 ...
Arnold, Tabuenca, Richard, Welling, Ajit K, Sachdeva, Patrice G, Blair, Karen, Horvath, John, Tarpley, John A, Savino, Richard, Gray, Julie, Gulley, Teresa, Arnold, Kevin, Wolfe, Donald A, Risucci   +11 more
openaire   +2 more sources