Results 91 to 100 of about 2,383,413 (297)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Equation-Free Multiscale Computational Analysis of Individual-Based Epidemic Dynamics on Networks

, 2010
The surveillance, analysis and ultimately the efficient long-term prediction and control of epidemic dynamics appear to be one of the major challenges nowadays. Detailed atomistic mathematical models play an important role towards this aim.
Aarts, Acuna-Soto, Agiza, Anderson, Bauch, Beauchemin, Benoit, Boccara, Bolker, Bollobás, Brauder, Burke, Cerny, Cisternas, Coifman, Constantinos I. Siettos, Edmunds, Eubank, Feng, Fenichel, Ferguson, Ferguson, Gaudart, Goussis, Gross, Hauerta, Hoya Whitea, Joo, Kavousanakis, Keeling, Keeling, Keller, Kelley, Kevrekidis, Kevrekidis, Kirkpatrick, Kolpas, Lam, Liu, Longini, Makeev, Makeev, Medley, Metropolis, Mooler, Mooller, Moon, Morens, Murray, Murrell, O’Malley, Pfeifer, Reppas, Ripley, Roy, Roy, Runborg, Saad, Severo, Siettos, Siettos, Spiliotis, Steger, Stone, Trevisanato, Vasil’eva, Wilson, Zietz   +67 more
core   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Toward smart and sustainable traffic solutions: a case study of the geography of transitions in urban logistics

Sustainability: Science, Practice, & Policy, 2020
City logistics as a research field offers a wide range of potential solutions and technologies for advancing toward modern and sustainable mobility. As societies demand environments that are more ecological and cities tackle the effects of growing e ...
Tim Fraske, Bernd Bienzeisler
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Dynamic Multi-Agent Based Variety Formation and Steering in Mass Customization [PDF]

Large product variety in mass customization involves a high internal complexity level inside a company’s operations, as well as a high external complexity level from a customer’s perspective.
Abdelkafi, Nizar, Blecker, Thorsten, Friedrich, Gerhard, Kreutler, Gerold   +3 more
core   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A multi-level perspective on perceived unmet needs for home support in home-dwelling older adults in the Swiss context: a secondary data analysis of a population study. [PDF]

BMC Geriatr, 2022
Mendieta MJ, De Geest SM, Goderis G, Yip O, Deschodt M, Dhaini S, INSPIRE Consortium.   +6 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source