Results 41 to 50 of about 348,151 (261)

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan   +3 more
wiley   +1 more source

A tug of war between centralization and decentralization: the co-evolution of urban governance and water risks in Guwahati, India

open access: yesEnvironmental Research Communications, 2023
Intermediate cities in Asia and Africa house more than 60% of the world’s urban population. More than 54% of the people here face high levels of water stress and are increasingly vulnerable to water-related risks such as floods, limited access to safe ...
Safa Fanaian, Farnoosh Fanaian
doaj   +1 more source

Reconnecting Farmers with Nature through Agroecological Transitions: Interacting Niches and Experimentation and the Role of Agricultural Knowledge and Innovation Systems

open access: yesAgriculture, 2022
Sustainability transitions in agriculture are explored through an analysis of niche initiatives within a common production system, relying on sustainable transitions, multi-level perspectives, and agroecological frameworks, and involving multi-actor ...
Cynthia Giagnocavo   +8 more
doaj   +1 more source

Demographic buffering in natural populations: multi-level perspective

open access: yesJournal of Animal Ecology
Environmental stochasticity impacts population dynamics and their viability. As such, understanding how organisms cope with this variability is crucial. Here, we investigate demographic buffering, the ability of populations to maintain stable growth despite environmental fluctuations.
Gabriel Santos   +4 more
openaire   +3 more sources

A Bibliometric Analysis of Publications in Uremic Toxins From 1991 to 2024

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Uremic toxins are a growing area of research in nephrology, with significant implications in the progression and treatment of chronic kidney disease (CKD) and the management of end‐stage kidney disease (ESKD). This bibliometric analysis aims to evaluate the global research trends, key contributors, and the impact of publications in ...
Yuh‐Shan Ho   +7 more
wiley   +1 more source

Socio-technical transition in the palm oil sector: analysis from a multilevel perspective in Colombia’s municipality of Tibú

open access: yesRevista de Economia e Sociologia Rural, 2023
Changes in the interactions between agents involved in the value chain of the palm oil sector in the municipality of Tibú (Colombia) over the period 1985-2020 have resulted in a reduction in the indices of poverty, social inequality, and unemployment for
José Ignacio Campos Naranjo   +1 more
doaj   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Community-Based Livestock Breeding: Coordinated Action or Relational Process?

open access: yesFrontiers in Veterinary Science, 2021
Over the past decade, community-based breeding programs (CBBPs) have been promoted as a viable approach to improving smallholder livelihoods through a systematic livestock breeding.
Maria Wurzinger   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

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