Results 61 to 70 of about 2,383,413 (297)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Agent-Based Modeling Framework for Electric Vehicle Adoption Transition in Indonesia

World Electric Vehicle Journal, 2021
Currently, the adoption of electric vehicles (EV) draws much attention, as the environmental issue of reducing carbon emission is increasing worldwide. However, different countries face different challenges during this transition, particularly developing
Dita Novizayanti, Eko Agus Prasetio, Manahan Siallagan, Sigit Puji Santosa   +3 more
doaj   +1 more source

Energy Storage Sharing Strategy in Distribution Networks Using Bi-level Optimization Approach

, 2017
In this paper, we address the energy storage management problem in distribution networks from the perspective of an independent energy storage manager (IESM) who aims to realize optimal energy storage sharing with multi-objective optimization, i.e ...
Chen, Huimiao, Hu, Zechun, Luo, Haocheng, Rajagopal, Ram, Tan, Chin-Woo, Yu, Yang   +5 more
core   +1 more source

All Who Wander: On the Prevalence and Characteristics of Multi-community Engagement [PDF]

, 2015
Although analyzing user behavior within individual communities is an active and rich research domain, people usually interact with multiple communities both on- and off-line. How do users act in such multi-community environments?
Argamon S., Berry J. W., Cheng J., Danescu-Niculescu-Mizil C., Erikson E. H., Kraut R. E., Lakkaraju H., M. E. Shaw. Group Dynamics, Simpson E. H., Yang J.   +9 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Defining the boundaries and operational concepts of resilience in the resilience in healthcare research program

BMC Health Services Research, 2020
Background Understanding the resilience of healthcare is critically important. A resilient healthcare system might be expected to consistently deliver high quality care, withstand disruptive events and continually adapt, learn and improve. However, there
Siri Wiig, Karina Aase, Stephen Billett, Carolyn Canfield, Olav Røise, Ove Njå, Veslemøy Guise, Cecilie Haraldseid-Driftland, Eline Ree, Janet E. Anderson, Carl Macrae, on behalf of the RiH-team   +11 more
doaj   +1 more source

Critical Review on Community-Shared Solar—Advantages, Challenges, and Future Directions

Energies, 2023
In the last few years, many innovative solutions have been presented to address the climate change crisis. One of the innovative solutions is the participation of community members in the collective production of solar electricity instead of individual ...
Nima Narjabadifam, Javanshir Fouladvand, Mustafa Gül   +2 more
doaj   +1 more source

'This is what democracy looks like' : New Labour's blind spot and peripheral vision [PDF]

, 2006
New Labour in government since 1997 has been roundly criticized for not possessing a clear, coherent and consistent democratic vision. The absence of such a grand vision has resulted, from this critical perspective, in an absence of 'joined-up' thinking ...
A Brazier, A Coulson, A Dinham, A Giddens, A Giddens, A McConnell, A Midwinter, A Trench, AH Birch, Bogdanor, C Jeffery, D Arter, D Judge, D Judge, D Judge, D Judge, D Judge, D Kavanagh, D McHugh, D Oliver, D Wilson, David Judge, DD Searing, E Shaw, G Allen, G Stoker, H Sullivan, H Sullivan, J Bartle, J Bradbury, J Curtice, J Mitchell, J Mitchell, J Morrison, J Radcliffe, KD Ewing, Lord Hailsham, M Aspinwall, M Evans, M Flinders, M Flinders, M Flinders, M Keating, M Rush, M Russell, M Shephard, N Bonney, N Johnson, P Cowley, P Cowley, P Mandelson, R Cook, R Stevens, S Low, S Ludlam, S Weir, SE Finer, T Blair, T Quinn, T Smith, T Wright, T Wright, V Lownes   +62 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source