Results 81 to 90 of about 5,150,898 (294)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Multi-field Modeling of Discrete Multi-link and Structural Shell System Stability

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2009
Technique and possibilities of a multi-field approach to modeling of stability of structural elastic systems are presented on examples of discrete multi-link system and periodically supported cylindrical shell.
A. A. Vasil'ev
doaj   +1 more source

Ordinal synchronization mark sequence and its steganography for a multi-link network covert channel. [PDF]

PLoS One, 2021
Fu S, Wang R, Dong L, Yan D.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Philosophiae botanicae novae seu institutionum phytographicarum prodromus

autore Frid. Link ..
Link, Heinrich Friedrich
core   +1 more source

Cross-Correlation of Large-Scale Parameters in Multi-Link Systems: Analysis Using the Box-Cox Transformation

IEEE Access, 2018
Spatially distributed transmission points connected to the same source, known as distributed antenna systems, can improve system performance compared with single-link traditional systems.
Ghassan Dahman, Jose Flordelis, Fredrik Tufvesson   +2 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Multi-Gigabit Wireless Link Development [PDF]

, 2007
CSIRO ICT Centre is developing millimetre wave point-to-point links suitable for multi-gigabit wireless connectivity. Suitable spectrum for this purpose is allocated at the 60 GHz band and above.
Bunton, J, Dyadyuk, V, Kendall, R, Shen, M, Smith, S, Abbott, D, Stokes, L, Sevimli, O   +7 more
core  

Multi-phase System Supplied by SVM VSI: A New Fast Algorithm to Compute Duty Cycles [PDF]

, 2004
La version éditeur de cette article est disponible à l'adresse suivante : http://www.epe-association.org/epe/index.phpMany authors proposed SVM VSI applied to multi-phase ...
HAUTIER, Jean-Paul, KESTELYN, Xavier, SEMAIL, Eric   +2 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source