Results 61 to 70 of about 5,150,898 (294)

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Link level modelling techniques for analysing the configuration of link adaptation algorithms in mobile radio networks [PDF]

open access: yes, 2004
The operation of Link Adaptation algorithms is based on channel quality estimates. It is therefore important to analyse the performance of such algorithms with link level models that properly capture the channel conditions and dynamics. Previous research
Gozalvez, J., Dunlop, J.
core   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Resource allocation optimization algorithm based on double populations differential evolution in WSN

open access: yesTongxin xuebao, 2018
A resource allocation algorithm was proposed for improving the network performance through jointing channel allocation,power control and timeslot allocation in multi-radio multi-channel wireless sensor network.More specifically,the network was modeled as
Xiaochen HAO   +4 more
doaj   +2 more sources

Greater Easterhouse multi-agency domestic violence forum: report on multi-agency day conference 22nd September 1998, Eastbank Health Promotion Centre [PDF]

open access: yes, 1998
This report provides highlights and delegate feedback from Greater Easterhouse Multi-Agency Domestic Violence Forum conference held September 1998. This brought together over 60 delegates from key agencies, representing a spread of senior managers and ...
Greater Easterhouse Multi-Agency Domestic Violence Forum
core   +1 more source

Out-Of-Plane Bending Stiffnesses in Offshore Mooring Chain Links Based on Conventional and Advanced Numerical Simulation Techniques

open access: yes한국해양공학회지, 2018
After an accident involving mooring link failures in an offloading buoy, verification of the fatigue safety in terms of the out-of-plane bending (OPB) and in-plane bending (IPB) moments has become a key engineering item in the design of various floating ...
Joonmo Choung   +2 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Research on a Critical Link Discovery Method for Network Security Situational Awareness

open access: yesEntropy
Network security situational awareness (NSSA) aims to capture, understand, and display security elements in large-scale network environments in order to predict security trends in the relevant network environment.
Guozheng Yang   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

open access: yesFEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee   +2 more
wiley   +1 more source

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