Results 41 to 50 of about 4,404,768 (300)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Multi-modal Embedding Fusion-based Recommender

CoRR, 2020
7 pages, 8 ...
Anna Wróblewska, Jacek Dabrowski 0004, Michal Pastuszak, Andrzej Michalowski, Michal Daniluk, Barbara Rychalska, Mikolaj Wieczorek, Sylwia Sysko-Romanczuk   +7 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Multi-sensor data fusion for urban area classification [PDF]

, 2011
Nowadays many sensors for information acquisition are widely employed in remote sensing and different properties of the objects can be revealed. Unfortunately each imaging sensor has its own limits on scene recognition in the sense of thematic, temporal,
Palubinskas, Gintautas, Gintautas Palubinskas, Reinartz, Peter, Makarau, Aliaksei, Aliaksei Makarau, Peter Reinartz   +5 more
core   +1 more source

Multi-Modal Object Detection Method Based on Dual-Branch Asymmetric Attention Backbone and Feature Fusion Pyramid Network

Remote Sensing
With the simultaneous acquisition of the infrared and optical remote sensing images of the same target becoming increasingly easy, using multi-modal data for high-performance object detection has become a research focus.
Jinpeng Wang, Nan Su, Chunhui Zhao, Yiming Yan, Shou Feng   +4 more
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Medical image fusion method by deep learning

International Journal of Cognitive Computing in Engineering, 2021
Deep learning technology has been extensively explored in pattern recognition and image processing areas. A multi-mode medical image fusion with deep learning will be proposed, according to the characters of multi-modal medical image, medical diagnostic ...
Yi Li, Junli Zhao, Zhihan Lv, Jinhua Li
doaj   +1 more source

Bayesian Fusion for Multi-Modal Aerial Images

Robotics: Science and Systems IX, 2013
This paper presents a fusion method to combine aerial images from a low flying Unmanned Aerial Vehicle (UAV) with images of other spectral bands from sources such as satellites or commercial hyperspectral imagers. The proposed method propagates information from high-resolution images into other low-resolution modalities while allowing the images to ...
Alistair Reid 0001, Fabio Ramos 0001, Salah Sukkarieh   +2 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source