Results 51 to 60 of about 4,404,768 (300)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Multi Sensor Image Fusion using Empirical Mode Decomposition [PDF]

open access: yes, 2013
Image fusion is a process of combining relevant information from two or more images from different sensors based on certain algorithm. Many algorithms have been proposed for pixel level image fusion.
Naidu, VPS, Shakthipriya, VS
core  

Medical image fusion: A survey of the state of the art [PDF]

open access: yes, 2014
Medical image fusion is the process of registering and combining multiple images from single or multiple imaging modalities to improve the imaging quality and reduce randomness and redundancy in order to increase the clinical applicability of medical ...
James, Alex Pappachen   +2 more
core   +1 more source

Multimodal Feature Fusion Method for Unbalanced Sample Data in Social Network Public Opinion

open access: yesSensors, 2022
With the wide application of social media, public opinion analysis in social networks has been unable to be met through text alone because the existing public opinion information includes data information of various modalities, such as voice, text, and ...
Jian Zhao   +6 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Multimodal biometrics score level fusion using non-confidence information [PDF]

open access: yes, 2011
Multimodal biometrics refers to automatic authentication methods that depend on multiple modalities of measurable physical characteristics. It alleviates most of the restrictions of single biometrics.
Chaw Poh, C
core  

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

open access: yesMolecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

open access: yesMolecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas   +16 more
wiley   +1 more source

Pathological Gait Classification Using Early and Late Fusion of Foot Pressure and Skeleton Data

open access: yesApplied Sciences
Classifying pathological gaits is crucial for identifying impairments in specific areas of the human body. Previous studies have extensively employed machine learning and deep learning (DL) methods, using various wearable (e.g., inertial sensors) and non-
Muhammad Tahir Naseem   +3 more
doaj   +1 more source

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