Results 111 to 120 of about 815,587 (296)

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Multi‐Objective Reinforcement Learning for Automated Resilient Cyber Defence

Applied AI Letters
Cyber‐attacks pose a security threat to military command and control networks, Intelligence, Surveillance, and Reconnaissance (ISR) systems, and civilian critical national infrastructure.
Ross O'Driscoll, Claudia Hagen, Joe Bater, James Adams   +3 more
doaj   +1 more source

Model Jaringan Distribusi Produk dengan Pendekatan Fuzzy Multi Objective Programming

Jurnal Optimasi Sistem Industri
PT. Semen Padang is one of the cement producers competing to meet the needs of the cement. To that end, PT. Semen Padang must ensure the availability of cement on time, quantity, location and at competitive rates.
Suci Oktri Viarani M Viarani, Henmaidi, Alexie Herryandie Bronto Adi   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

A Single Period Multi Objective Mathematical Model for Portfolio

مدیریت تولید و عملیات, 2015
Optimal portfolio selection and how to invest in, is one of the key issues which is considered in the capital market and should be paid attention by investors.
mehdi abzari, ahmad dadashpor, mehdi khalili, hamid jamshidi   +3 more
doaj  

Multi‐objective multi‐period optimal site and size of distributed generation along with network reconfiguration

IET Renewable Power Generation
While extensive research has focused on enhancing distribution networks through either maximizing Distributed Generation (DG) integration or network reconfiguration at specific times, there is a need for further investigation into concurrently optimal ...
Ghulam Abbas, Zhi Wu, Aamir Ali
doaj   +1 more source