Results 121 to 130 of about 6,112,119 (319)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Multi-objective optimization techniques in electricity generation planning

, 2011
The objective of this research is to develop a framework of multi-objective optimization (MOO) models that are better capable of providing decision support on future long-term electricity generation planning (EGP), in the context of insufficient ...
Tuyiragize, Richard, Richard Tuyiragize
core  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

An investigation of multi-objective hyper-heuristics for multi-objective optimisation [PDF]

, 2014
In this thesis, we investigate and develop a number of online learning selection choice function based hyper-heuristic methodologies that attempt to solve multi-objective unconstrained optimisation problems. For the first time, we introduce an online learning selection choice function based hyperheuristic framework for multi-objective optimisation. Our
openaire   +2 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Multi‐Objective Reinforcement Learning for Automated Resilient Cyber Defence

Applied AI Letters
Cyber‐attacks pose a security threat to military command and control networks, Intelligence, Surveillance, and Reconnaissance (ISR) systems, and civilian critical national infrastructure.
Ross O'Driscoll, Claudia Hagen, Joe Bater, James Adams   +3 more
doaj   +1 more source

Model Jaringan Distribusi Produk dengan Pendekatan Fuzzy Multi Objective Programming

Jurnal Optimasi Sistem Industri
PT. Semen Padang is one of the cement producers competing to meet the needs of the cement. To that end, PT. Semen Padang must ensure the availability of cement on time, quantity, location and at competitive rates.
Suci Oktri Viarani M Viarani, Henmaidi, Alexie Herryandie Bronto Adi   +2 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Design of Fluid Power Systems Using a Multi-Objective Genetic Algorithm

, 2004
This book presents an extensive variety of multi-objective problems across diverse disciplines, along with statistical solutions using multi-objective evolutionary algorithms (MOEAs). The topics discussed serve to promote a wider understanding as well as
Ölvander, Johan,
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source