Results 81 to 90 of about 596,735 (263)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Multi‐Objective Reinforcement Learning for Automated Resilient Cyber Defence

Applied AI Letters
Cyber‐attacks pose a security threat to military command and control networks, Intelligence, Surveillance, and Reconnaissance (ISR) systems, and civilian critical national infrastructure.
Ross O'Driscoll, Claudia Hagen, Joe Bater, James Adams   +3 more
doaj   +1 more source

Model Jaringan Distribusi Produk dengan Pendekatan Fuzzy Multi Objective Programming

Jurnal Optimasi Sistem Industri
PT. Semen Padang is one of the cement producers competing to meet the needs of the cement. To that end, PT. Semen Padang must ensure the availability of cement on time, quantity, location and at competitive rates.
Suci Oktri Viarani M Viarani, Henmaidi, Alexie Herryandie Bronto Adi   +2 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

A Single Period Multi Objective Mathematical Model for Portfolio

مدیریت تولید و عملیات, 2015
Optimal portfolio selection and how to invest in, is one of the key issues which is considered in the capital market and should be paid attention by investors.
mehdi abzari, ahmad dadashpor, mehdi khalili, hamid jamshidi   +3 more
doaj  

Multi‐objective multi‐period optimal site and size of distributed generation along with network reconfiguration

IET Renewable Power Generation
While extensive research has focused on enhancing distribution networks through either maximizing Distributed Generation (DG) integration or network reconfiguration at specific times, there is a need for further investigation into concurrently optimal ...
Ghulam Abbas, Zhi Wu, Aamir Ali
doaj   +1 more source