Results 81 to 90 of about 815,587 (296)
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Multi‐objective decision‐making for road design
Transport, 2008 Multi‐objective analysis is a popular tool to solve many economic, managerial and construction problems. The objective of this research is to develop and implement a methodology for multi‐objective optimization of multi‐alternative decisions in road ...
Willem Karel M. Brauers +3 more
doaj
Multi‐Objective Optimisation Framework for Heterogeneous Federated Learning
CAAI Transactions on Intelligence TechnologyFederated learning is a distributed framework that trains a centralised model using data from multiple clients without transferring that data to a central server.
Jamshid Tursunboev +4 more
doaj +1 more source
Evidence of coevolution in multi-objective evolutionary algorithms [PDF]
, 2009 This paper demonstrates that simple yet important characteristics of coevolution can occur in evolutionary algorithms when only a few conditions are met.
Whitacre, Dr James M
core +2 more sources
Multi-object spectroscopy in space
SPIE Proceedings, 1998 From the scientific objectives of the Next Generation Space Telescope, this paper tries to constrain the design of the NGST Multi-Object Spectrograph. Several technical alternatives are presented that could address the requirements of the Design Reference Mission.
Burgarella, D. +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Anytime Algorithms for Multi-Objective Hub Location Problems [PDF]
, 2018 In many logistic, telecommunications and computer networks, direct routing of commodities between any origin and destination is not viable due to economic and technological constraints.
Chicano, Francisco +3 more
core
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source