Results 101 to 110 of about 1,341,500 (277)

Deep Collaborative Innovation Product Decision-Making Model Based on Multi-Objective Optimization

IEEE Access
With the advancement of societal living standards, the cultural and creative industry (CCI) facing the challenge of balancing user demands, market demands, and the preservation of traditional culture.
Kunrong Zhao, Xuerui Li, Xinggang Hou, Yehui Zhang   +3 more
doaj   +1 more source

An Improved SPEA2 Algorithm with Local Search for Multi-Objective Investment Decision-Making

Applied Sciences, 2019
Enterprise investment decision-making should not only consider investment profits, but also investment risks, which is a complex nonlinear multi-objective optimization problem.
Xi Liu, Dan Zhang
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Intelligent decision-making for TBM tunnelling control parameters using multi-objective optimization

Journal of Rock Mechanics and Geotechnical Engineering
In tunnel construction, tunnel boring machine (TBM) tunnelling typically relies on manual experience with sub-optimal control parameters, which can easily lead to inefficiency and high costs.
Shaokang Hou, Yaoru Liu, Jialin Yu, Rujiu Zhang, Li Cheng, Chenfeng Gao   +5 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Multi-objective Multiplexer Decision Making Benchmark Problem

Proceedings of the Companion Conference on Genetic and Evolutionary Computation, 2023
Boris Djartov, Sanaz Mostaghim
openaire   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Multi-Criteria Optimal Planning for Energy Policies in CLP [PDF]

, 2014
In the policy making process a number of disparate and diverse issues such as economic development, environmental aspects, as well as the social acceptance of the policy, need to be considered.
Bragaglia, Stefano, Cagnoli, Paolo, Chesani, Federico, Gavanelli, Marco, Marengo, Elisa, Milano, Michela   +5 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source