Results 71 to 80 of about 845,538 (282)

Optimum Nozzle Design for a Viscous Liquid by Using Multi-Objective Search Approaches

IEEE Access, 2020
This work deals with the problem of a nozzle design addressed through a multi-objective optimization strategy where governing equations of fluid dynamics model the phenomena.
Victor Dario Cuervo Pinto, Alejandro Rodriguez-Molina, Leonel German Corona-Ramirez, Miguel Gabriel Villarreal-Cervantes   +3 more
doaj   +1 more source

Efficient Hill Climber for Multi-Objective Pseudo-Boolean Optimization [PDF]

, 2016
Chicano, F., Whitley D., & Tinós R. (2016). Efficient Hill Climber for Multi-Objective Pseudo-Boolean Optimization. 16th European Conference on Evolutionary Computation for Combinatorial Optimization (LNCS 9595), pp.
Chicano, Francisco, Tinós, Renato, Whitley, Darrell   +2 more
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Multi-objective optimization framework for networked predictive controller design

, 2013
Networked Control Systems (NCSs) often suffer from random packet dropouts which deteriorate overall system's stability and performance. To handle the ill effects of random packet losses in feedback control systems, closed over communication network, a ...
Das, Saptarshi, Das, Sourav, Pan, Indranil   +2 more
core   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Hybrid Metaheuristics for Multi-Objective Optimization

Journal of Algorithms & Computational Technology, 2015
Over the last two decades, interest on hybrid metaheuristics has risen considerably in the field of multi-objective optimization (MOP). The best results found for many real-life or academic multi-objective optimization problems are obtained by hybrid ...
E-G. Talbi
doaj   +1 more source

Multi-disciplinary shape optimization of an entry capsule integrated with custom neural network approximation and multi-delity approach [PDF]

, 2011
This paper describes a new integrated approach for the multi-disciplinary optimization of a entry capsule’s shape. Aerothermodynamics, Flight Mechanics and Thermal Protection System behaviour of a reference spaceship when crossing Martian atmosphere are ...
Cavallero, Claudio, Chiarelli, Cosimo, Davite, Alessio, Gallizio, Federico, Mareschi, Vincenzo, Minisci, Edmondo, Sudars, Martins   +6 more
core  

Multi-Objective Conjunctive Use Optimization

Critical Transitions in Water and Environmental Resources Management, 2004
This paper presents a simulation/optimiza tion model based on artificial neural networks and genetic algorithms for solving multi -objective conjunctive water use problems. The model simulates and optimizes water flows in a hydraulically connected reservoir-stream-aquifer system.
Fayad, H. C., Peralta, Richard C.
openaire   +3 more sources

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source