Results 31 to 40 of about 10,517,802 (309)
Reliability based design optimization of a two-stage wind turbine gearbox
Mechanics & IndustryThis paper describes a multi-objective reliability-based design optimization (MORBDO) of a two-stage wind turbine gearbox. The optimization process incorporates the gear's reliability of accounting for the uncertainty of its internal geometric parameters.
Karmi Bilel +6 more
doaj +1 more source
Shanghai Jiaotong Daxue xuebao, 2022 The failure of modular multilevel converter (MMC) submodules in the flexible direct current (DC) system affects the normal operation of the system, and the mutual restriction of reliability and economy is one of the key issues of MMC redundancy ...
MA Zhoujun, WANG Yong, WANG Jie, CHEN Shaoyu
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT We assessed the effect of iron overload (IO) on mortality and complications following hematopoietic stem cell transplantation (HSCT) in patients with Diamond–Blackfan anemia syndrome (DBAS) in a systematic review of individual participant data and cohort data from observational studies.
Geoffrey Z. L. Kuppens +6 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Jixie qiangdu, 2022 In view of the effect of random uncertain factors such as the material properties of the turning shaft and different load conditions on its performance, and reduce its weight to improve fuel economy.Through the finite element modeling of the dump truck ...
ZHOU Song +6 more
doaj
Energy Reports, 2023 This paper introduces a novel approach to simultaneously optimize the reliability and efficiency of a switching power supply (SPS) using the Non-dominated Sorting Genetic Algorithm (NSGA-II) and Honey Bee Algorithm (HBA).
Seyed Mehdi Nouri +2 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Research on Deployment Strategy of Multi-Level Controller in Software Defined Satellite Network
IEEE AccessThe delay, load, reliability and other factors of Software Defined Satellite Network are affected by the dynamic network topology. The location and number of controllers deployed are important factors affecting the performance of satellite networks ...
Yingjie Wang, Zhongmin Pei, Zhangkai Luo
doaj +1 more source
Multi-objective Reliability Optimization of a Pharmaceutical Plant by NSGA-II
, 2022 AbstractThis work addresses the use of a MO optimization algorithm to deal with the reliability optimization problem in order to determine the redundancy and reliability of each component in the system. Often, these problems are formulated as a single-objective problem with mixed variables (real-integer) and is subject to various design constraints ...
Billal Nazim Chebouba +2 more
openaire +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source