Results 41 to 50 of about 10,517,802 (309)

Dynamics Optimization Research and Dynamics Accuracy and Reliability Analysis of a Multi-Link Mechanism with Clearances

Machines, 2022
With the development of high-speed and lightweight mechanisms, and the continuous improvement of manufacturing accuracy requirements in industrial production, clearance joints have increasingly become one of the key factors affecting dynamics performance.
Shuai Jiang, Yuanpeng Lin, Jianan Liu, Linjing Xiao, Shuaishuai Zhang   +4 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Multi-objective reliability design optimization of electric multiple unit pantograph geometric parameters

Advances in Mechanical Engineering, 2016
In order to reduce the design variable fluctuations in the multi-objective optimization of the pantograph geometric parameters of electric multiple units, a multi-objective reliability design optimization method was proposed based on the dual response ...
Bingzhi Chen, Yonghua Li, Shaodi Dong, Jian Wang   +3 more
doaj   +1 more source

Multi-Objective Optimization for Submarine Cable Route Planning Based on the Ant Colony Optimization Algorithm

Photonics, 2023
It is essential to design an appropriate submarine cable route to reduce costs and improve reliability. A methodology that can be used for multi-objective optimization in submarine cable route planning is proposed and numerically studied in this paper ...
Zanshan Zhao, Jingting Wang, Guanjun Gao, Haoyu Wang, Daobin Wang   +4 more
doaj   +1 more source

Multi-objective optimization for a reliable localization scheme in wireless sensor networks

Journal of Communications and Networks, 2016
In many wireless sensor network (WSN) applications, the information transmitted by an individual entity or node is of limited use without the knowledge of its location. Research in node localization is mostly geared towards multi-hop range-free localization algorithms to achieve accuracy by minimizing localization errors between the node's actual and ...
Farrukh Shahzad 0001, Tarek R. Sheltami, Elhadi M. Shakshuki   +2 more
openaire   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Learning-based ship design optimization approach [PDF]

, 2012
With the development of computer applications in ship design, optimization, as a powerful approach, has been widely used in the design and analysis process.
Turan, Osman, Cui, Hao, Sayer, Philip
core   +4 more sources

Reliability-Aware Multi-Objective Optimization-Based Routing Protocol for VANETs Using Enhanced Gaussian Mutation Harmony Searching

IEEE Access, 2022
Vehicular Ad Hoc Networks (VANETs) is an emerging technology that can be applied in intelligent transportation systems. Routing protocols are essential for obtaining reliable VANET networks.
Sami Abduljabbar Rashid, Mohammed Alhartomi, Lukman Audah, Mustafa Maad Hamdi   +3 more
doaj   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source