Results 81 to 90 of about 5,551,543 (292)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Multi-modal characterization of nanogram amounts of a photosensitive polymer

open access: yes, 2013
Here, we demonstrate multi-modal approach of simultaneous characterization of poly(vinyl cinnamate) (PVCN) using a microcantilever sensor. We integrate nanomechanical thermal analysis with photothermal cantilever deflection spectroscopy for discerning ...
Jeon, S   +11 more
core   +1 more source

Determinants of undergraduate bioscience engagement: Validating attendance barriers and classroom spatial behaviour across institutions

open access: yesFEBS Open Bio, EarlyView.
Student engagement extends beyond simple attendance. Across 891 bioscience students from three universities, attendance behaviour was associated mainly with structural influences, whereas classroom spatial behaviour reflected affective and sensory factors.
Nigel Page   +4 more
wiley   +1 more source

A Framework for Multi-Physics Modeling, Design Optimization and Uncertainty Quantification of Fast-Spectrum Liquid-Fueled Molten-Salt Reactors

open access: yesApplied Sciences
The analysis of liquid-fueled molten-salt reactors (LFMSRs) during steady state, operational transients and accident scenarios requires addressing unique reactor multi-physics challenges with coupling between thermal hydraulics, neutronics, inventory ...
David Holler   +4 more
doaj   +1 more source

A Discrete/Continuous Numerical Approach to Multi-physics

open access: yesIFAC-PapersOnLine, 2015
Abstract A variety of technical applications are not only the physics of a single domain, but include several physical phenomena, and therefore are referred to as multi-physics. As long as the phenomena being taken into account is either continuous or discrete i.e. Euler or Lagrangian a homogeneous solution concept can be employed.
PETERS, Bernhard   +4 more
openaire   +2 more sources

Exploration of Strong Field Physics with Multi-PW Lasers

open access: yes, 2018
At the Center for Relativistic Laser Science (CoReLS) petawatt (PW) lasers have been developed for the investigations of strong field physics. The CoReLS has successfully upgraded one of the existing PW laser beamlines to a 4 PW laser at 20 fs.
Choi, Il Woo   +4 more
core   +1 more source

Hydrogel platforms for 3D cardiac tissue engineering and fibrotic disease modelling

open access: yesFEBS Open Bio, EarlyView.
Hydrogel‐based cardiac tissue models are advancing our understanding of heart health and disease. By incorporating electrical conductivity, aligned structures, and tunable mechanical properties, these platforms better replicate the complex environment of native heart tissue.
Harrison Porritt   +2 more
wiley   +1 more source

Advancements in PARCS/TRACE Coupling and Simulation of Rod Ejection Accident in VVER-1000 Nuclear Reactor

open access: yesEnergies
As the global energy demand continues to grow and the pursuit of clean and sustainable resources intensifies, nuclear energy stands out as a secure, reliable, and low-emission solution.
Gianluca Nesti   +3 more
doaj   +1 more source

CMS physics technical design report, volume II: Physics performance

open access: yes, 2007
CMS is a general purpose experiment, designed to study the physics of pp collisions at 14 TeV at the Large Hadron Collider (LHC). It currently involves more than 2000 physicists from more than 150 institutes and 37 countries.
Physics Collaboration   +1 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

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