Results 31 to 40 of about 34,547 (261)
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Yuanzineng kexue jishuAccurate analysis of reactor core behavior to unlock traditional design margins and enhance the economic efficiency of nuclear power plants has become a key research direction in current reactor design and development.
ZENG Wei1, 2, WANG Jie1, WANG Xiaoyu1, LI Zhigang1, PAN Junjie1, TANG Qifen1
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Materials & DesignIn hybrid laser-MIG(Metal Inert Gas) welding, multi-physics field prediction in the melting pool is crucial for process optimization and quality control.
Wenbo Zhou +4 more
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Discrete multi-physics: A mesh-free model of blood flow in flexible biological valve including solid aggregate formation. [PDF]
PLoS ONE, 2017 We propose a mesh-free and discrete (particle-based) multi-physics approach for modelling the hydrodynamics in flexible biological valves. In the first part of this study, the method is successfully validated against both traditional modelling techniques
Mostapha Ariane +6 more
doaj +1 more source
Nuclear Engineering and Technology, 2023 The multi-physics coupled methodologies that have been widely used to analyze the complex process occurring in nuclear reactors have also been used to the R&D of numerical reactors.
Guan-Hua Qian +6 more
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Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
A parallelized model for coupled phase field and crystal plasticity simulation [PDF]
Computer Methods in Materials Science, 2016 The predictive simulation of materials with strong interaction between microstructural evolution and mechanical deformation requires the coupling of two or more multi-physics models.
Mingxuan Lin, Ulrich Prahl
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Nuclear Engineering and Technology, 2023 The k-eigenvalue neutronics/thermal-hydraulics coupling calculation is a key issue for reactor design and analysis. Jacobian-free Newton-Krylov (JFNK) method, featured with super-linear convergence rate and high efficiency, has been attracting more and ...
Lixun Liu +5 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source