A nonlinear multi-scale model for blood circulation in a realistic vascular system [PDF]
Royal Society Open Science, 2021 In the last decade, numerical models have become an increasingly important tool in biological and medical science. Numerical simulations contribute to a deeper understanding of physiology and are a powerful tool for better diagnostics and treatment.
Ulin Nuha A. Qohar +3 more
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A Multi-Scale Model for Cholera Outbreaks
Mathematics, 2022 Cholera, caused by the pathogenic Vibrio cholerae bacteria, remains a severe public health threat. Although a lot of emphasis has been placed on the population-level spread of the disease, the infection itself starts within the body.
Beryl Musundi +2 more
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A Novel Stochastic Multi-Scale Model of Francisella tularensis Infection to Predict Risk of Infection in a Laboratory [PDF]
Frontiers in Microbiology, 2018 We present a multi-scale model of the within-phagocyte, within-host and population-level infection dynamics of Francisella tularensis, which extends the mechanistic one proposed by Wood et al. (2014). Our multi-scale model incorporates key aspects of the
Jonathan Carruthers +5 more
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Phenotypic selection through cell death: stochastic modelling of O-6-methylguanine-DNA methyltransferase dynamics [PDF]
Royal Society Open Science, 2020 Glioblastoma (GBM) is the most aggressive malignant primary brain tumour with a median overall survival of 15 months. To treat GBM, patients currently undergo a surgical resection followed by exposure to radiotherapy and concurrent and adjuvant ...
Ayoub Lasri +7 more
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Opportunities and Challenges in Building a Spatiotemporal Multi-scale Model of the Human Pancreatic β Cell. [PDF]
Cell, 2018 Singla J +5 more
europepmc +2 more sources
A Multi-Scale Numerical Model for Investigation of Flame Dynamics in a Thermal Flow Reversal Reactor
Energies, 2022 In this paper, the flame dynamics in a thermal flow reversal reactor are studied using a multi-scale model. The challenges of the multi-scale models lie in the data exchanges between different scale models and the capture of the flame movement of the ...
Jia Li +5 more
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Diversity, 2023 The influence of landscape structure on species communities is intimately connected to the spatial scales at which measurements are made. If we do not measure landscape structure at its most impactful scale, otherwise known as the “scale of effect”, we ...
Qian Mao +6 more
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Frontiers in Pharmacology, 2020 Tuberculosis (TB) remains as one of the world's deadliest infectious diseases despite the use of standardized antibiotic therapies. Recommended therapy for drug-susceptible TB is up to 6 months of antibiotics.
Joseph M. Cicchese +4 more
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Analysis of Hydrostatic Bearings Based on a Unstructured Meshing Scheme and Turbulence Model
Machines, 2022 Guideway hydrostatic bearings with the function of supporting and moving loads are a key component of ultra-precision heavy-duty machine tools. Because the dimension difference between the oil gap and the overall structure is great, it is difficult to ...
Yingjie Wang, Hao Wu, Youmin Rong
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Root System Scale Models Significantly Overestimate Root Water Uptake at Drying Soil Conditions
Frontiers in Plant Science, 2022 Soil hydraulic conductivity (ksoil) drops significantly in dry soils, resulting in steep soil water potential gradients (ψs) near plant roots during water uptake.
Deepanshu Khare +5 more
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