Results 111 to 120 of about 9,428,499 (297)

Multi-scale computational fluid dynamics for dense gas-solid flows using DEM as numerical laboratory [PDF]

, 2007
No ...
van Sint Annaland, M., Hoef, van der, M.A., Kuipers, J.A.M.; id_orcid, van der Hoef, Martin Anton, Kuipers, JAM Hans, Deen, N.G., Deen, NG Niels, Sint Annaland, M Martin van, Kuipers, J.A.M., Sint Annaland, van, M., Hoef, MA Martin van der, Deen, N.G.; id_orcid   +11 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

A Note on Equivalences in Measuring Returns to Scale in Multi-output-multi-input Technologies [PDF]

In this article we show equivalence between the input oriented and output oriented scale elasticity measures for multi-output, multi-input technologies. We show the necessary and sufficient condition for this equivalence.
Valentin Zelenyuk
core  

EPOS Multi-scale laboratories Data Services & Trans-national access program

, 2020
EGU2020: Sharing Geoscience Online, 4-8 May, 2020EPOS (European Plate Observing System) is an ESFRI Landmark and European Research Infrastructure Consortium (ERIC).
Fernandez-Turiel, J. L., Lange, O., Wessels, R., EPOS TCS Multi-scale laboratories Team (WP16)   +3 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Synergy-CLIP: Extending CLIP With Multi-Modal Integration for Robust Representation Learning

IEEE Access
Multi-modal representation learning has become a pivotal area in artificial intelligence, enabling the integration of diverse modalities such as vision, text, and audio to solve complex problems.
Sangyeon Cho, Jangyeong Jeon, Mingi Kim, Junyeong Kim   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Adaptive Event-Driven Labeling: Multi-Scale Causal Framework with Meta-Learning for Financial Time Series

Applied Sciences
Financial time-series labeling remains fundamentally limited by three critical deficiencies: temporal rigidity (fixed horizons regardless of market conditions), scale blindness (single-resolution analysis), and correlation-causation conflation.
Amine Kili, Brahim Raouyane, Mohamed Rachdi, Mostafa Bellafkih   +3 more
doaj   +1 more source