Results 91 to 100 of about 1,700,637 (286)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Enhanced Window-Based Self-Attention with Global and Multi-Scale Representations for Remote Sensing Image Super-Resolution

Remote Sensing
Transformers have recently gained significant attention in low-level vision tasks, particularly for remote sensing image super-resolution (RSISR). The vanilla vision transformer aims to establish long-range dependencies between image patches.
Yuting Lu, Shunzhou Wang, Binglu Wang, Xin Zhang, Xiaoxu Wang, Yongqiang Zhao   +5 more
doaj   +1 more source

Identification and estimation of latent attitudes and their behavioral implications [PDF]

This paper (i) formalizes conditions under which a population distribution of categorical responses to attitudinal questions (Ñ©temsÒ© has a scale representation; (ii) develops tests for whether a particular sample of item responses is consistent with a ...
Richard Spady
core  

Face Recognition by Cortical Multi-scale Line and Edge Representations [PDF]

, 2006
Empirical studies concerning face recognition suggest that faces may be stored in memory by a few canonical representations. Models of visual perception are based on image representations in cortical area V1 and beyond, which contain many cell layers for feature extraction. Simple, complex and end-stopped cells provide input for line, edge and keypoint
Rodrigues, J. M. F., du Buf, J. M. H.
openaire   +2 more sources

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

YOLO-SAR: An Enhanced Multi-Scale Ship Detection Method in Low-Light Environments

Applied Sciences
Nowadays, object detection has become increasingly crucial in various Internet-of-Things (IoT) systems, and ship detection is an essential component of this field.
Zihang Xiong, Mei Wang, Ruixiang Kan, Jiayu Zhang   +3 more
doaj   +1 more source

Multi-Scale Representation Learning for Protein Fitness Prediction

Advances in Neural Information Processing Systems 37
Designing novel functional proteins crucially depends on accurately modeling their fitness landscape. Given the limited availability of functional annotations from wet-lab experiments, previous methods have primarily relied on self-supervised models trained on vast, unlabeled protein sequence or structure datasets.
Zuobai Zhang, Pascal Notin, Yining Huang, Aurélie C. Lozano, Vijil Chenthamarakshan, Debora S. Marks, Payel Das, Jian Tang 0005   +7 more
openaire   +4 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source