Results 81 to 90 of about 1,700,637 (286)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

HieraASGSegNet: Hierarchical Context Fusion for Semantic Segmentation via Adaptive Superpixel Graph Reasoning

IEEE Access
Semantic segmentation remains challenging in real-world scenes due to variations in object scale, frequent occlusions, and ambiguous boundaries. We propose HieraASGSegNet, a hierarchical segmentation framework that performs adaptive superpixel graph ...
Jinliang Liang, Gang Wei
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Generative artificial intelligence for sustainable architectural design within urban contexts: evaluating potentials, constraints, and barriers through cost–dissimilarity scenario analysis

Frontiers in Sustainable Cities
Generative Artificial Intelligence (AI) is increasingly used to support early-stage sustainable architectural and urban design through the rapid production of technical representations.
Francesco Sica, Giuseppe Cerullo, Francesco Tajani   +2 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PerMSCA-YOLO: A Perceptual Multi-Scale Convolutional Attention Enhanced YOLOv8 Model for Rail Defect Detection

Applied Sciences
With the widespread application of high-speed and heavy-load railways, the real-time detection of track surface defects has become increasingly crucial. To address the challenges in rail defect detection, this study proposes the PerMSCA-YOLO model, which
Jialiang Zhang, Ruiqi Zhang, Fengkai Luan, Hu Zhang   +3 more
doaj   +1 more source

Multi-Scale Integrated Analysis of Societal and Ecosystem Metabolism (MUSIASEM): An Outline of Rationale and Theory [PDF]

This paper presents an outline of rationale and theory of the MuSIASEM scheme (Multi-Scale Integrated Analysis of Societal and Ecosystem Metabolism).
Jesus Ramos-Martín, Kozo Mayumi, Mario Giampietro   +2 more
core  

Holistic mesoscale modelling of concrete – recent developments [PDF]

, 2017
Modelling of concrete at the mesoscale is needed in many applications, but developing a realistic mesoscale model for the analysis of concrete behaviour under general loading conditions is challenging.
Lu, Yong, Zhou, Rongxin
core  

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Multi-scale Cortical Keypoint Representation for Attention and Object Detection [PDF]

, 2005
Keypoints (junctions) provide important information for focus-of-attention (FoA) and object categorization/recognition. In this paper we analyze the multi-scale keypoint representation, obtained by applying a linear and quasi-continuous scaling to an optimized model of cortical end-stopped cells, in order to study its importance and possibilities for ...
Rodrigues, J. M. F., du Buf, J. M. H.
openaire   +2 more sources