Results 71 to 80 of about 175,074 (267)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Remote Sensing, 2015 The satellite-derived growing season time-integrated Normalized Difference Vegetation Index (GSN) has been used as a proxy for vegetation biomass productivity.
Yingxin Gu, Bruce K. Wylie
doaj +1 more source
Multi-Sensor System Calibrations
, 2018 Many applications in robotics require awareness of the state of the robot and its environment. Faced with ambiguities arising in measurements from any single sensor, many applications turn to integrating multiple sensors with often complementary characteristics. This work addresses calibration of multi-sensor systems.
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Assessing the Performance of a Northern Gulf of Mexico Tidal Model Using Satellite Imagery
Remote Sensing, 2013 Tidal harmonic analysis simulations along with simulations spanning four specific historical time periods in 2003 and 2004 were conducted to test the performance of a northern Gulf of Mexico tidal model.
Stephen C. Medeiros +7 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
SensorsIn recent years, offshore wind farms have frequently encountered engineering geological disasters such as seabed liquefaction and scouring. Consequently, in situ monitoring has become essential for the safe siting, construction, and operation of these ...
Miaojun Sun +6 more
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Remote Sensing, 2016 Although the past few decades have witnessed the great development of Synthetic Aperture Radar Interferometry (InSAR) technology in the monitoring of landslides, such applications are limited by geometric distortions and ambiguity of 1D Line-Of-Sight ...
Qian Sun, Jun Hu, Lei Zhang, Xiaoli Ding
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source