Results 81 to 90 of about 644,997 (352)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A hibernating multi-swarm optimization algorithm for dynamic environments [PDF]

2010 Second World Congress on Nature and Biologically Inspired Computing (NaBIC), 2010
Many problems in the real world are dynamic in which the environment changes. However, the nature itself provides solutions for adaptation to these changes in order to gain the maximum benefit, i.e. finding the global optimum, at any moment. One of these solutions is hibernation of animals when food is scarce and an animal may use more energy in ...
Masoud Kamosi, Ali B. Hashemi, M.R. Meybodi   +2 more
openaire   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Resilient Task Allocation for UAV Swarms: A Bilevel PSO-ILP Optimization Approach

Drones
To address the severe challenges of task allocation for UAV swarms in uncertain complex environments, this paper introduces the concept of equivalent load, constructs the load capability matrix of a single UAV and the task required load matrix of the ...
Yifan Zeng, Linghua Wu, Jinning Li, Xuebin Zhuang, Cailun Wu   +4 more
doaj   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Metaheuristic-Driven Optimization of a Neural Model Using Tuna Swarm Intelligence for Cognitive Classification of Wheat Species

International Journal of Computational Intelligence Systems
Accurate classification of wheat varieties is vital for enhancing agricultural productivity and maintaining food quality standards. However, conventional methods based on manual inspection are time-consuming, labor-intensive, and prone to human error ...
Beytullah Yağız, Erdal Eker, Yener Altun, Şeyma Nur Atar, Davut Izci, Serdar Ekinci, Mohit Bajaj, Mohammad Shabaz   +7 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Distributed Parallel Particle Swarm Optimization for Multi-Objective and Many-Objective Large-Scale Optimization

IEEE Access, 2017
With the advent of big data era, complex optimization problems with many objectives and large numbers of decision variables are constantly emerging. Traditional research about multi-objective particle swarm optimization (PSO) focuses on multi-objective ...
Bin Cao, Jianwei Zhao, Zhihan Lv, Xin Liu, Shan Yang, Xinyuan Kang, Kai Kang   +6 more
doaj   +1 more source