Results 61 to 70 of about 86,218 (261)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Deep Multi‑view Clustering with Dual‑Channel Granular Computing

Nanjing Hangkong Hangtian Daxue Xuebao
In order to deal with the problems of quality differences among different views， ambiguous boundary samples and differences in semantic structures among different views， we propose deep multi-view clustering with dual-channel granular computing.
CAI Chaoyue, MA Xingru, GUO Jing, HU Xin, JU Hengrong, DING Weiping   +5 more
doaj   +1 more source

Multi-View Clustering

, 2018
With a plethora of data capturing modalities becoming available, the same data object often leaves different kinds of digital footprints. This naturally leads to datasets comprising the same set of data objects represented in different forms, called multi-view data.
Padmanabhan, Deepak, Jurek-Loughrey, Anna   +1 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spectral clustering with distinction and consensus learning on multiple views data.

PLoS ONE, 2018
Since multi-view data are available in many real-world clustering problems, multi-view clustering has received considerable attention in recent years. Most existing multi-view clustering methods learn consensus clustering results but do not make full use
Peng Zhou, Fan Ye, Liang Du
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Robust Multi-View Clustering With a Unified Weight Learning Paradigm

IEEE Access, 2019
Multi-view clustering, which exploits multi-view information to improve the clustering performance has attracted much attention in recent years. However, existing methods seldom consider the diverse quality of data points in different views, and assign ...
Miaomiao Li, Zhenglai Li, Chang Tang, Xinwang Liu, Lulu Wang   +4 more
doaj   +1 more source

Unsupervised radar signal recognition based on multi‐block – Multi‐view Low‐Rank Sparse Subspace Clustering

IET Radar, Sonar & Navigation, 2022
In the field of radar reconnaissance, unsupervised recognition of radar signals is a particularly important method for classifying different signals and estimating signal parameters.
Lutao Liu, Shuai Xu
doaj   +1 more source

Adversarial fair multi-view clustering

Pattern Recognition
Cluster analysis is a fundamental problem in data mining and machine learning. In recent years, multi-view clustering has attracted increasing attention due to its ability to integrate complementary information from multiple views. However, existing methods primarily focus on clustering performance, while fairness-a critical concern in human-centered ...
Mudi Jiang, Jiahui Zhou, Lianyu Hu, Xinying Liu, Zengyou He, Zhikui Chen   +5 more
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source