Results 41 to 50 of about 21,136,484 (286)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Cell Classification Based on Artificial Intelligence Analysis of Cell Images in Microfluidic Chip
Engineering Proceedings, 2023 We developed a low-cost, multi-classification, label-free and high-precision method for cell classification, which combines microfluidic technology with a deep learning algorithm. The recognition of the states of red blood cells was selected as a typical
Yuping Yang, Shunbo Li
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Joint Supervised Dictionary and Classifier Learning for Multi-View SAR Image Classification
IEEE Access, 2019 A new multi-view sparse representation classification (SRC) algorithm based on joint supervised dictionary and classifier learning (MSRC-JSDC) is proposed for synthetic aperture radar (SAR) image classification. Unlike most existing sparse representation
Haohao Ren +4 more
doaj +1 more source
Hierarchical Multi-Label Object Detection Framework for Remote Sensing Images
Remote Sensing, 2020 Detecting objects such as aircraft and ships is a fundamental research area in remote sensing analytics. Owing to the prosperity and development of CNNs, many previous methodologies have been proposed for object detection within remote sensing images ...
Su-Jin Shin +3 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
EnzML : multi-label prediction of enzyme classes using InterPro signatures [PDF]
, 2012 LDF is funded by ONDEX DTG, BBSRC TPS Grant BB/F529038/1 of the Centre for Systems Biology at Edinburgh and the University of Newcastle. SA is supported by by a Wellcome Trust Value In People award and, together with IG, the Centre for Systems Biology at
Goryanin Igor +14 more
core +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source