Results 51 to 60 of about 38,424 (250)

Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease

open access: yesJournal of Cardiovascular Development and Disease, 2018
The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac ...
Catherine E. Lipovsky   +3 more
doaj   +1 more source

A Multi-parametric Programming Based Analytic Method to Compute Consumer Offer Curve for Reserves

open access: yesJournal of Modern Power Systems and Clean Energy, 2022
An analytic method is proposed to compute the price-reserve offer curve at the consumer level in hierarchical direct load control. The convexification of the consumer reserve provision is examined, and the analytic expression of the optimal solution ...
Weiye Zheng, David J. Hill, Wenchuan Wu
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Dataset used to develop soft computing models that predict the stiffness modulus of bituminous mixtures

open access: yesData in Brief
This data article presents information on the measurement of Indirect Tensile Stiffness Modulus of laboratory and field asphalt mixtures. The asphalt mixes are composed of three distinct binders that were categorised by their penetration grade (40/55-TLA,
Lee P. Leon   +3 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

MINLP model for operation optimization of multi-source single-sink liquid light hydrocarbon pipeline network system

open access: yesYou-qi chuyun, 2020
At present, batch mixed transportation mode is mainly adopted in the multi-source single-sink liquid light hydrocarbon pipeline network system of China's oil and gas fields.
Rui QIU   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Predicting compressive strength of eco-friendly plastic sand paver blocks using gene expression and artificial intelligence programming

open access: yesScientific Reports, 2023
Plastic sand paver blocks provide a sustainable alternative by using plastic waste and reducing the need for cement. This innovative approach leads to a more sustainable construction sector by promoting environmental preservation.
Bawar Iftikhar   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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